FBXL5 and SNAI1

Number of citations of the paper that reports this interaction (PMID 24157836)
1

Data Source:
BioGRID (enzymatic study)

		FBXL5	SNAI1
Gene Name		F-box and leucine-rich repeat protein 5	snail family zinc finger 1
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Kinase Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Iron Ion Homeostasis Positive Regulation Of Cellular Protein Catabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Palate Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Tight Junction Assembly
Pathways		Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS			Psoriasis ( 20953189)
Protein-Protein Interactions		8 interactors: CSNK2B DCTN1 EP300 NABP2 ORC4 PLK1 SKP1 SNAI1	19 interactors: ACTN2 CTDSP1 CTDSP2 CTDSPL FBXL14 FBXL5 GSK3B HIST1H3A HOXD4 KRT31 KRT40 KRTAP10-3 LATS2 MID2 MTUS2 NOTCH1 NOTCH2NL RCOR1 TRIM23
Entrez ID		26234	6615
HPRD ID		05739	05025
Ensembl ID		ENSG00000118564	ENSG00000124216
Uniprot IDs		Q9UKA1	O95863
PDB IDs		3U9J 3U9M 3V5X 3V5Y 3V5Z	2Y48
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Notch Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone H2B Acetylation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Metabolic Process Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Activation Of APC-Cdc20 Complex Activity Positive Regulation Of Transferase Activity Cellular Response To Stimulus Response To Unfolded Protein Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Stress N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Binding Positive Regulation Of Cellular Protein Catabolic Process Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Response To Endoplasmic Reticulum Stress Mitotic Cell Cycle Checkpoint Polar Body Extrusion After Meiotic Divisions Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Protein Phosphorylation Circadian Rhythm Regulation Of Protein Kinase Activity	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphorylation Protein Localization To Microtubule Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Cellular Protein Modification Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Protein Localization To Cytoskeleton Cellular Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Neuron Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Protein Ubiquitination Regulation Of Protein Phosphorylation Wound Healing Positive Regulation Of Stem Cell Differentiation Protein Modification By Small Protein Conjugation Epithelial To Mesenchymal Transition Epidermis Development Venous Endothelial Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Protein Metabolic Process Negative Regulation Of Neurogenesis Regulation Of Developmental Growth Response To Wounding Regulation Of Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Cell Development Negative Regulation Of Type B Pancreatic Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Cardiac Right Atrium Morphogenesis Mitral Valve Formation Superior Temporal Gyrus Development Negative Regulation Of Biosynthetic Process Keratinocyte Differentiation Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process
Tagcloud ?		cacybp carrying concept demethylase disability dosage encoding epigenetic functionally homologue insights intellectual interdependent kdm5c kdm5d lysine males marks methylation neurodevelopment neurodevelopmental normally occurring parallel promoters scmh1 sex shed top	aberrations apart aspect ccnd1 clinicopathological copy covered encompassed endometrial erbb1 erbb2 erbb3 erbb4 esr1 frequent infiltration insufficient myometrial pakt1 pgr pik3ca prom1 rad21 rad27 runx1 scgb2a2 snai2 top2a younger
Tagcloud (Difference) ?		cacybp carrying concept demethylase disability dosage encoding epigenetic functionally homologue insights intellectual interdependent kdm5c kdm5d lysine males marks methylation neurodevelopment neurodevelopmental normally occurring parallel promoters scmh1 sex shed top	aberrations apart aspect ccnd1 clinicopathological copy covered encompassed endometrial erbb1 erbb2 erbb3 erbb4 esr1 frequent infiltration insufficient myometrial pakt1 pgr pik3ca prom1 rad21 rad27 runx1 scgb2a2 snai2 top2a younger
Tagcloud (Intersection) ?