PFDN6 and THAP11

Number of citations of the paper that reports this interaction (PubMedID 18330356)
0

Data Source:
BioGRID (two hybrid)

		PFDN6	THAP11
Description		prefoldin subunit 6	THAP domain containing 11
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GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex Protein-containing Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Folding Protein Stabilization Chaperone-mediated Protein Complex Assembly Negative Regulation Of Amyloid Fibril Formation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Electron Transport Chain Neuron Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Transcription
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061 29483656)
Interacting Genes		13 interacting genes: AIMP2 B4GALT2 CCHCR1 CEBPA CEBPG FBXO2 KANK2 KIFC3 MAGEB4 MBD3 PFDN5 RPRD1B THAP11	21 interacting genes: BBLN CASP3 CEBPA CFTR ECT2 HCFC1 HDAC1 HDAC3 HEMGN L3MBTL2 LRRC45 MCPH1 NUTF2 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52
Entrez ID		10471	57215
HPRD ID		16135	11629
Ensembl ID		ENSG00000204220	ENSG00000168286
Uniprot IDs		O15212 Q5STK2	Q96EK4
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7	2LAU 5AJS
Enriched GO Terms of Interacting Partners?			Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Negative Regulation Of RNA Biosynthetic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Chromatin Binding Histone Deacetylase Binding Histone Deacetylase Complex Transcription Corepressor Binding Transcription Repressor Complex Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Protein Lysine Deacetylase Activity General Transcription Initiation Factor Binding Response To Ketone Negative Regulation Of Biosynthetic Process Chromatin DNA Binding Rhythmic Process Protein-containing Complex Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Nucleus Sin3-type Complex Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Microtubule Cytoskeleton Organization Involved In Mitosis Response To Glucocorticoid Mitotic Spindle Heterochromatin Formation NF-kappaB Binding Cellular Developmental Process Regulation Of Protein Stability Regulation Of Macromolecule Metabolic Process Cell Differentiation Response To Corticosteroid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity
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