PFDN6 and B4GALT2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PFDN6	B4GALT2
Gene Name		prefoldin subunit 6	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Golgi Membrane Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Unfolded Protein Binding Chaperone Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Galactosyltransferase Activity Metal Ion Binding
	Biological Process	Protein Folding Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Chaperone-mediated Protein Complex Assembly	Carbohydrate Metabolic Process Pathogenesis Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding	Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective EXT2 causes exostoses 2 Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: B4GALT2 PFDN5 THAP11	1 interactors: PFDN6
Entrez ID		10471	8704
HPRD ID		16135	04928
Ensembl ID		ENSG00000204220	ENSG00000117411
Uniprot IDs		O15212 Q5STK2	O60909
PDB IDs
Enriched GO Terms of Interacting Partners?			Chaperone-mediated Protein Complex Assembly 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding
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