CHMP2B and PHGDH

Number of citations of the paper that reports this interaction (PMID 16730941)
46

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHMP2B	PHGDH
Gene Name		charged multivesicular body protein 2B	phosphoglycerate dehydrogenase
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Late Endosome Membrane Extracellular Vesicular Exosome	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding	Phosphoglycerate Dehydrogenase Activity Electron Carrier Activity NAD Binding
	Biological Process	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Process Endosomal Transport Viral Life Cycle Viral Budding Via Host ESCRT Complex Membrane Organization Regulation Of Mitotic Spindle Assembly	Glutamine Metabolic Process Glycine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Cellular Amino Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Neuron Projection Development Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process G1 To G0 Transition
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	Serine biosynthesis Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives
Drugs			NADH
Diseases
GWAS			Metabolic traits ( 21886157) Metabolite levels ( 23378610)
Protein-Protein Interactions		11 interactors: ATP5C1 CENPF CHMP3 DPY30 MALSU1 PHGDH PNMA1 TERF2IP TRAF2 USP54 USP8	5 interactors: APP CHMP2B MAPK6 PIAS4 SUMO4
Entrez ID		25978	26227
HPRD ID		13174	06047
Ensembl ID		ENSG00000083937	ENSG00000092621
Uniprot IDs		B2RE76 Q9UQN3	O43175
PDB IDs		2JQK	2G76
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Mitochondrial Translation Regulation Of Organelle Organization Negative Regulation Of Chromosome Organization Cell Division	Protein Sumoylation Positive Regulation Of Keratinocyte Apoptotic Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Peptidyl-lysine Modification Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Viral Budding Via Host ESCRT Complex Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Protein Modification Process Regulation Of Mitotic Spindle Assembly Neuron Remodeling Viral Budding Regulation Of Spindle Assembly Positive Regulation Of Protein Sumoylation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Spindle Organization Cellular Copper Ion Homeostasis Cell Separation After Cytokinesis Regulation Of Cell Cycle Process Regulation Of Protein Sumoylation Copper Ion Homeostasis Suckling Behavior Cellular Protein Metabolic Process Virion Assembly
Tagcloud ?		c9orf72 complexities counseling ethical fad familial frame frontotemporal ftd fus genetics grn gwas helping hexanucleotide mapt modifying multifactorial navigate pathogenetic presenilin progranulin psen1 psen2 reading tarbdp tardna valosin vcp	amplified apoptotic biosynthesis catalyzes de deprivation dramatically frequently inhibits knockdown limiting melanoma melanomas mutated notably novo nutlin p53 promotes regulating retain reveal rnai sensitize serine starvation step suppresses suppressing
Tagcloud (Difference) ?		c9orf72 complexities counseling ethical fad familial frame frontotemporal ftd fus genetics grn gwas helping hexanucleotide mapt modifying multifactorial navigate pathogenetic presenilin progranulin psen1 psen2 reading tarbdp tardna valosin vcp	amplified apoptotic biosynthesis catalyzes de deprivation dramatically frequently inhibits knockdown limiting melanoma melanomas mutated notably novo nutlin p53 promotes regulating retain reveal rnai sensitize serine starvation step suppresses suppressing
Tagcloud (Intersection) ?