GART and IFNAR1

		GART	IFNAR1
Description		phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Lysosome Endosome Late Endosome Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity ATP Binding Transferase Activity Ligase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Metal Ion Binding	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Cytokine Binding Type I Interferon Binding
	Biological Process	Brainstem Development Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cerebellum Development Cerebral Cortex Development 'de Novo' AMP Biosynthetic Process Adenine Biosynthetic Process 'de Novo' XMP Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Respiration
Pathways		Purine ribonucleoside monophosphate biosynthesis	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs		Pemetrexed Glycinamide Ribonucleotide N-({4-[(1R)-4-[(2R,4S,5S)-2,4-diamino-6-oxohexahydropyrimidin-5-yl]-1-(2,2,2-trifluoro-1,1-dihydroxyethyl)butyl]phenyl}carbonyl)-L-glutamic acid	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Peginterferon beta-1a Anifrolumab Human interferon beta Ropeginterferon alfa-2b
Diseases
GWAS		Crohn's disease ( 23128233) Educational attainment ( 25201988) Psoriasis ( 25854761)	Blood protein levels ( 30072576) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		5 interacting genes: CDC42 KPNA2 OGT PXN TRAF6	26 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK LRPAP1 MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		2618	3454
HPRD ID		00716	00126
Ensembl ID		ENSG00000159131	ENSG00000142166
Uniprot IDs		P22102 Q59HH3	A0A8V8TQK8 A0A994J6F6 P17181
PDB IDs		1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 2QK4 2V9Y 4EW1 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ2 4ZZ3 5J9F 7JG0 7JG3 7JG4 8FDX 8FDY 8FE0 8FJV 8FJW 8FJX 8FJY 9NX6	3S98 3SE3 3SE4 4PO6 8Y31
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Communication Intracellular Signaling Cassette Regulation Of Signaling Myeloid Leukocyte Differentiation Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Cell-cell Junction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Myeloid Cell Differentiation Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Macrophage Activation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cell Surface Receptor Signaling Pathway Via JAK-STAT Mononuclear Cell Differentiation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Host-mediated Perturbation Of Viral Process Cell Surface Receptor Signaling Pathway Via STAT Leukocyte Differentiation GBD Domain Binding Storage Vacuole Type I Interferon Receptor Activity Type I Interferon Binding Interferon Receptor Activity Leading Edge Cell Differentiation Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Response To Virus Positive Regulation Of Cell Population Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Population Proliferation Regulation Of Cell Migration	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Type I Interferon-mediated Signaling Pathway Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Cytokine Receptor Binding Regulation Of Hemopoiesis T Cell Activation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Type I Interferon Receptor Binding Regulation Of Cytokine Production Cellular Response To Virus Positive Regulation Of Signal Transduction Protein Modification Process Natural Killer Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Exogenous DsRNA Regulation Of Intracellular Signal Transduction Cell Activation Involved In Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Developmental Process Leukocyte Activation Response To DsRNA Positive Regulation Of Immune System Process B Cell Activation Regulation Of Multicellular Organismal Process Immune System Process Lymphocyte Activation Natural Killer Cell Activation Cell Activation Phosphate-containing Compound Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Gene Expression
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?