SMC4

Description		structural maintenance of chromosomes 4
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Speck Nuclear Lumen
	Molecular Function	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Mitotic Sister Chromatid Segregation Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Malaria ( 31844061)
Interacting Genes		6 interacting genes: CEBPA NCAPD2 PTEN SMC2 SUMO2 TRAF3IP1
Entrez ID		10051
HPRD ID		09276
Ensembl ID		ENSG00000113810
Uniprot IDs		B3KXX5 E9PD53 Q58F29 Q9NTJ3
PDB IDs		4U4P
Enriched GO Terms of Interacting Partners?		Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Chromosome Condensation Mitotic Chromosome Condensation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Chromosome Segregation Nuclear Chromosome Positive Regulation Of Chromosome Separation Condensed Chromosome Chromosome Condensation Condensed Nuclear Chromosome Nucleoplasm Chromosome Organization Involved In Meiotic Cell Cycle Regulation Of Cell Cycle Regulation Of Proteolysis Regulation Of Chromosome Separation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Organelle Organization Positive Regulation Of Catabolic Process Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Chromosome Organization Regulation Of Protein Metabolic Process Regulation Of Chromosome Segregation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Osteoblast Differentiation Embryonic Organ Development White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Phosphate Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex
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