ALKBH4 and TXNL4B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALKBH4	TXNL4B
Description		alkB homolog 4, lysine demethylase	thioredoxin like 4B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Midbody Contractile Ring	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Actin Binding Protein Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity Protein Demethylase Activity DNA N6-methyladenine Demethylase Activity	Protein Binding
	Biological Process	Chromatin Organization Actomyosin Structure Organization Cleavage Furrow Ingression Demethylation Positive Regulation Of Gene Expression, Epigenetic	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS		Morning person ( 30696823)	Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 30718733 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Red blood cell count ( 32888494) Total cholesterol levels ( 30718733) Triglyceride levels ( 32154731 32203549)
Interacting Genes		19 interacting genes: BPIFA1 DTX2 EIF3C EP300 FAM168A GORASP2 HSF4 LCN2 MLLT1 MLLT3 MTMR6 NIF3L1 PSMA6 TCF4 TES TRAF4 TXNL4B WEE2-AS1 ZFHX3	13 interacting genes: AIPL1 ALKBH4 BHLHE40 MEOX1 MEOX2 PICK1 PLEKHF2 PNMA5 PRPF6 REL SF1 SPG21 TCF4
Entrez ID		54784	54957
HPRD ID		07875	11655
Ensembl ID		ENSG00000160993	ENSG00000140830
Uniprot IDs		Q9NXW9	Q9NX01
PDB IDs			1XBS 3GIX 4IN0 8Y6O
Enriched GO Terms of Interacting Partners?			Somite Specification Segment Specification Somite Development DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Limb Development E-box Binding Spliceosomal Complex Assembly Farnesylated Protein Binding DNA N6-methyladenine Demethylase Activity Embryonic Pattern Specification Cleavage Furrow Ingression Positive Regulation Of Transcription By RNA Polymerase II Sclerotome Development Beta-catenin-TCF7L2 Complex Protein Farnesylation
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