EPC2 and NMI

		EPC2	NMI
Description		enhancer of polycomb 2	N-myc and STAT interactor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function		Protein Binding Identical Protein Binding
	Biological Process	DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Protein K48-linked Ubiquitination Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K48-linked Ubiquitination
Pathways			SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 21123754) Chronotype ( 30696823) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Relative amplitude of rest-activity cycles ( 30120083) Schizophrenia ( 29483656 30285260) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		2 interacting genes: EED EZH2	57 interacting genes: ANKRD13C-DT BRAT1 BRCA1 BRMS1 C1orf216 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EXOSC5 GCSH GOLGA8EP HDDC3 HGS HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN MYOM3 NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 THAP8 TRAF5 TRIM72 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I
Entrez ID		26122	9111
HPRD ID		13274	04632
Ensembl ID		ENSG00000135999	ENSG00000123609
Uniprot IDs		Q52LR7	Q13287
PDB IDs
Enriched GO Terms of Interacting Partners?		Pronucleus ESC/E(Z) Complex Facultative Heterochromatin Formation Chromatin Silencing Complex Nucleosome Binding Transcription Corepressor Binding Hepatocyte Homeostasis Peptidase Complex Cellular Response To Trichostatin A Melanocyte Apoptotic Process Regulation Of Adaxial/abaxial Pattern Formation Heterochromatin Formation Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Melanocyte Proliferation Regulation Of Collagen Catabolic Process Negative Regulation Of Interferon-alpha Production Histone H3K27 Methyltransferase Activity Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Cerebellar Cortex Development Sex Chromatin Primary MiRNA Binding Negative Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Keratinocyte Differentiation Cobalamin Metabolic Process Cellular Response To Antibiotic Subtelomeric Heterochromatin Formation Negative Regulation Of Extracellular Matrix Disassembly Molecular Carrier Activity Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cytokine Production Negative Regulation Of Epidermal Cell Differentiation Dipeptidyl-peptidase Activity G1 To G0 Transition Positive Regulation Of Dendrite Development Negative Regulation Of Interferon-beta Production Positive Regulation Of Protein Modification Process Basal Part Of Cell Regulation Of Fibrinolysis Positive Regulation Of Protein Polyubiquitination	Nucleoplasm Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Population Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Programmed Cell Death Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Population Proliferation Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sin3-type Complex Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation DNA-templated Transcription Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Development Of Secondary Sexual Characteristics Positive Regulation Of Gene Expression Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Metabolic Process
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