ANKRD17 and ADH6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ANKRD17	ADH6
Gene Name		ankyrin repeat domain 17	alcohol dehydrogenase 6 (class V)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Membrane	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Binding Poly(A) RNA Binding	Alcohol Dehydrogenase (NAD) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Zinc Ion Binding Ethanol Binding
	Biological Process	Blood Vessel Maturation Regulation Of DNA Replication Viral Process Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Ethanol Oxidation Xenobiotic Metabolic Process Small Molecule Metabolic Process Response To Ethanol
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Ethanol oxidation Metabolic disorders of biological oxidation enzymes Defective CYP1B1 causes Glaucoma Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Alcohol dependence ( 23456092) Esophageal cancer ( 19698717) QRS duration ( 23534349)
Protein-Protein Interactions		5 interactors: ADH6 APC ITSN2 KIAA0368 MDM2	8 interactors: ANKRD17 ARRB1 KRAS RASSF5 RPAIN RPS29 RSL1D1 TNIP1
Entrez ID		26057	130
HPRD ID		10648	00067
Ensembl ID		ENSG00000132466	ENSG00000172955
Uniprot IDs		E7EUV3 O75179	E9PBI1 P28332 Q8IUN7
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cellular Macromolecule Catabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Odontogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Response To Vitamin B1 Response To Ether Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Response To UV-C Negative Regulation Of Protein Processing Proteolysis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Regulation Of Protein Catabolic Process Positive Regulation Of Pseudopodium Assembly Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Export From Nucleus Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Negative Regulation Of Intracellular Signal Transduction Ethanol Oxidation Negative Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Catabolic Process Response To Magnesium Ion Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Cell Cycle Process Cellular Response To Antibiotic Negative Regulation Of Cell Cycle Arrest Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Positive Regulation Of Ras Protein Signal Transduction Response To Light Stimulus Positive Regulation Of Small GTPase Mediated Signal Transduction Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Radiation Regulation Of MAPK Cascade Positive Regulation Of Rac Protein Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of MDA-5 Signaling Pathway Response To Stress Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Smooth Muscle Cell Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Modification Process Positive Regulation Of RIG-I Signaling Pathway
Tagcloud ?		add african alleles americans antihypertensive caucasian caucasians connections cox18 displaying diuretics elevations fto grin3a hctz heterozygotes hydrochlorothiazide hyperuricaemia luc7l2 padi4 pard3b pear pharmacogenomic replicated rs4784333 suggestive thiazide ua uric	aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 flnc gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?		add african alleles americans antihypertensive caucasian caucasians connections cox18 displaying diuretics elevations fto grin3a hctz heterozygotes hydrochlorothiazide hyperuricaemia luc7l2 padi4 pard3b pear pharmacogenomic replicated rs4784333 suggestive thiazide ua uric	aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 flnc gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?