EGFL6 and OFD1

Data Source: HiPPIP (Novel)

		EGFL6	OFD1
Name		EGF like domain multiple 6	OFD1 centriole and centriolar satellite protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Membrane Extracellular Matrix	Extracellular Region Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Membrane Motile Cilium Centriolar Satellite Ciliary Basal Body Cell Projection
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding	Protein Binding Identical Protein Binding Alpha-tubulin Binding Gamma-tubulin Binding Molecular Adaptor Activity
	Biological Process	Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Differentiation Extracellular Matrix Organization	Mitotic Cell Cycle Centriole Replication Embryonic Body Morphogenesis Cell Projection Organization Axoneme Assembly Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Mitotic Spindle Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation
Pathways		None	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Diseases		None	Oral-facial-digital syndrome 1 Joubert syndrome
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165 ) Multiple sclerosis ( 23412934 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: OFD1	2 novel interactors: EGFL6 RAI2
Interacting Genes		3 interacting genes: SH3GL2 SH3GL3 UBQLN2	9 interacting genes: AKT1 CCSER2 CEP126 EIF6 GPRASP1 LUC7L2 NME7 RUVBL1 S100A6
Entrez ID		25975	8481
HPRD ID		02212	02162
Ensembl ID		ENSG00000198759	ENSG00000046651
Uniprot IDs		Q8IUX8	E9KL37 O75665
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Regulation Of Clathrin-dependent Endocytosis Regulation Of Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Identical Protein Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Endocytosis Central Nervous System Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Blood-brain Barrier Permeability Presynapse Postsynaptic Endosome Photoreceptor Ribbon Synapse Early Endosome Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus Body Morphogenesis Embryonic Body Morphogenesis Lipid Binding Dendrite Extension Regulation Of Transport Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Endocytosis Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Vascular Permeability Postsynaptic Density, Intracellular Component Negative Regulation Of Transport Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Postsynaptic Cytoskeleton Organization Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Centriole Replication Regulation Of ERAD Pathway Glutamatergic Synapse Presynaptic Cytosol Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Centriole Assembly Import Into Cell Negative Regulation Of ERBB Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Gamma-tubulin Binding Organelle Organization Presynaptic Endocytosis Regulation Of Cellular Component Organization Response To Nerve Growth Factor Regulation Of Vascular Permeability Endosome	None