KIAA0319

Description		KIAA0319
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GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Protein Binding
	Biological Process	Neuron Migration Nervous System Development Sensory Perception Of Sound Response To Auditory Stimulus Thalamus Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Multicellular Organismal Response To Stress Vocal Learning Negative Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Dendrite Development
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Radiation response ( 20923822) Serum uric acid levels ( 30993211) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		3 interacting genes: APP FEM1B SH2B1
Entrez ID		9856
HPRD ID		18713
Ensembl ID		ENSG00000137261
Uniprot IDs		A0A087X0U9 Q5VV43
PDB IDs		2E7M
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Epithelial Cell Maturation Involved In Prostate Gland Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Cycle Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle
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