SYF2 and MCM3

Number of citations of the paper that reports this interaction (PubMedID 16951160)
0

Data Source:
BioGRID (pull down, pull down)

		SYF2	MCM3
Description		SYF2 pre-mRNA splicing factor	minichromosome maintenance complex component 3
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Chromosome Nucleolus Cytoplasm Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding DNA Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Processing Mitotic G2 DNA Damage Checkpoint Signaling Gastrulation Positive Regulation Of Cell Population Proliferation RNA Splicing Embryonic Organ Development	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation
Pathways		mRNA Splicing - Major Pathway	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Glycated hemoglobin levels ( 28898252 34059833) Lead levels ( 26025379) Male-pattern baldness ( 27182965 29146897) Mean corpuscular volume ( 27863252) Plateletcrit ( 27863252) Urate levels in obese individuals ( 25811787)	Cryptococcosis in HIV infection ( 33269293)
Interacting Genes		5 interacting genes: APP ARMC7 CCNDBP1 MCM3 MLH1	37 interacting genes: ATRIP CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 FILNC1 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ
Entrez ID		25949	4172
HPRD ID		07386	04072
Ensembl ID		ENSG00000117614	ENSG00000112118
Uniprot IDs		O95926	A0A0S2Z492 A0A0S2Z4T1 A0A499FHX9 B4DUQ9 J3KQ69 P25205
PDB IDs		5MQF 5XJC 5YZG 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8I0U 8I0V 8I0W 8RO2 9FMD	6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Mitotic DNA Replication Initiation Single-stranded DNA Binding Alpha DNA Polymerase:primase Complex Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Chiasma Late Recombination Nodule Mismatch Repair Complex Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Double-strand Break Repair Positive Regulation Of Isotype Switching To IgA Isotypes DNA Recombination	DNA Replication Initiation DNA Metabolic Process DNA Replication Nucleic Acid Metabolic Process DNA Replication Origin Binding Double-strand Break Repair Via Break-induced Replication Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response CMG Complex MCM Complex Regulation Of DNA Metabolic Process Regulation Of DNA Replication DNA Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of DNA-templated DNA Replication Initiation Macromolecule Metabolic Process Nucleus Double-strand Break Repair DNA Recombination Single-stranded DNA Binding Regulation Of Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Chromosome Negative Regulation Of Cell Cycle Phase Transition Nuclear Origin Of Replication Recognition Complex Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Single-stranded DNA Helicase Activity DNA Damage Checkpoint Signaling Origin Recognition Complex Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Signal Transduction In Response To DNA Damage DNA Helicase Activity Response To Stress Sister Chromatid Cohesion Prp19 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated DNA Replication ATP Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Helicase Activity Cyclin E1-CDK2 Complex
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