SAMHD1 and KIZ

Data Source: HiPPIP (Novel)

		SAMHD1	KIZ
Name		SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	kizuna centrosomal protein
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain	Cytoplasm Centrosome Cytoskeleton Cell Projection
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Catalytic Activity RNA Nuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Hydrolase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding Metal Ion Binding Deoxynucleoside Triphosphate Hydrolase Activity	Protein Binding Protein Kinase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Immune System Process DGTP Catabolic Process DNA Replication DNA Repair Immune Response DNA Damage Response Deoxyribonucleotide Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Innate Immune Response Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway DNA Strand Resection Involved In Replication Fork Processing	Spindle Organization
Pathways		Nucleotide catabolism Interferon alpha/beta signaling	None
Diseases		Aicardi-Goutieres Syndrome (AGS)	None
GWAS		Caffeine consumption from coffee or tea ( 33287642 ) Height ( 28552196 )	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Appendicular lean mass ( 33097823 ) Autism spectrum disorder ( 30804558 ) Height ( 31562340 )
Novel Interactors		3 novel interactors: AAR2 KIZ XPO1	10 novel interactors: AAR2 ANKEF1 CDK5RAP1 EIF2S2 NKX2-2 OVOL2 PRND RASSF2 SAMHD1 SPEF1
Interacting Genes		15 interacting genes: ACTB APP ARAP3 CDK1 CHUK DYSF FAM13B FBXO25 FBXO7 IKBKB NONO SUMO2 TIRAP TRIM21 USP7	4 interacting genes: CRYAA MEOX2 TACC3 TFIP11
Entrez ID		25939	55857
HPRD ID		08418	12760
Ensembl ID		ENSG00000101347	ENSG00000088970
Uniprot IDs		A0A2R8YCS7 Q59H15 Q9Y3Z3	A0A087X251 Q2M2Z5
PDB IDs		2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM 7A5Y 7LTT 7LU5 7S2Y 7UJN 8D94 8D9J 8GB1 8GB2 8QXJ 8QXK 8QXL 8QXM 8QXN 8QXO 8TDV 8TDW 9EC2	Not available
GO Terms Enriched among Interactors		Regulation Of Innate Immune Response IkappaB Kinase Activity Post-translational Protein Modification Regulation Of Cellular Component Organization Innate Immune Response CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Transferrin Receptor Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response IkappaB Kinase Complex Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Positive Regulation Of Defense Response Defense Response To Other Organism Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Catabolic Process Regulation Of Circadian Rhythm Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Immune System Process Regulation Of Type I Interferon Production Protein Ubiquitination Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Immune System Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Response To Copper Ion Regulation Of Proteolysis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex Immune Response	Protein-containing Complex Organization Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment DGTPase Activity DGTP Binding Triphosphoric Monoester Hydrolase Activity Deoxynucleoside Triphosphate Hydrolase Activity Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity