ZDHHC5 and GLYAT

Data Source: HiPPIP (Novel)

		ZDHHC5	GLYAT
Name		zDHHC palmitoyltransferase 5	glycine-N-acyltransferase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Plasma Membrane Membrane Dendrite Synapse Phagocytic Vesicle Postsynapse Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Protein Binding Transferase Activity Acyltransferase Activity Glycine N-acyltransferase Activity Glycine N-benzoyltransferase Activity
	Biological Process	Immune System Process Lipid Transport Fatty Acid Transport Protein Palmitoylation Protein Catabolic Process Response To Muramyl Dipeptide Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Protein Maturation Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Localization To Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Phagocytic Vesicle	Glycine Metabolic Process Acyl-CoA Metabolic Process Xenobiotic Metabolic Process Response To Toxic Substance Monocarboxylic Acid Metabolic Process Benzoyl-CoA Metabolic Process
Pathways		Maturation of spike protein	Conjugation of salicylate with glycine Conjugation of benzoate with glycine Aspirin ADME
Drugs		None	Glycine
GWAS		Anxiety ( 33859377 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General factor of neuroticism ( 30867560 ) Neuroticism ( 29255261 ) Schizophrenia ( 25056061 28991256 29483656 ) Sociability score ( 34054130 ) Worry too long after an embarrassing experience ( 34054130 )	Body mass (lean) ( 23108985 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Diastolic blood pressure ( 27841878 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Hepcidin/ferritin ratio ( 27846281 ) Monocyte count ( 32888494 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 ) Ulcerative colitis ( 28067908 )
Interacting Genes		1 interacting genes: SRPK2	9 interacting genes: CYSRT1 GPRASP1 KRTAP1-1 KRTAP1-3 KRTAP10-8 NBPF19 NOTCH2NLA PTN RBM48
Entrez ID		25921	10249
HPRD ID		15720	07603
Ensembl ID		ENSG00000156599	ENSG00000149124
Uniprot IDs		Q9C0B5	A0A384P5E3 Q6IB77
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Benzoyl-CoA Metabolic Process Glycine N-benzoyltransferase Activity Regulation Of Viral Life Cycle Regulation Of Viral Process Glycine N-acyltransferase Activity Nuclear Speck Organization	Keratin Filament Intermediate Filament