ZDHHC5 and MS4A6A

Data Source: HiPPIP (Novel)

		ZDHHC5	MS4A6A
Name		zDHHC palmitoyltransferase 5	membrane spanning 4-domains A6A
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Plasma Membrane Membrane Dendrite Synapse Phagocytic Vesicle Postsynapse Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component	Trans-Golgi Network Plasma Membrane Membrane
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Protein Binding
	Biological Process	Immune System Process Lipid Transport Fatty Acid Transport Protein Palmitoylation Protein Catabolic Process Response To Muramyl Dipeptide Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Protein Maturation Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Localization To Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Phagocytic Vesicle	Cell Surface Receptor Signaling Pathway
Pathways		Maturation of spike protein	None
GWAS		Anxiety ( 33859377 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General factor of neuroticism ( 30867560 ) Neuroticism ( 29255261 ) Schizophrenia ( 25056061 28991256 29483656 ) Sociability score ( 34054130 ) Worry too long after an embarrassing experience ( 34054130 )	Alzheimer's disease ( 21460840 ) Alzheimer's disease (late onset) ( 24162737 28714976 30617256 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) C-reactive protein levels ( 30388399 ) Cerebrospinal fluid sTREM-2 levels ( 31708768 ) Factor VII activity ( 30642921 ) Factor VII activity or levels ( 30642921 ) Family history of Alzheimer's disease ( 30617256 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 26561523 28107422 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 30598549 28869591 ) Lymphocyte percentage of white cells ( 32888494 ) Methadone dose in opioid dependence ( 28115739 ) Neutrophil count ( 32888494 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Interacting Genes		1 interacting genes: SRPK2	1 interacting genes: GPRC5D
Entrez ID		25921	64231
HPRD ID		15720	09414
Ensembl ID		ENSG00000156599	ENSG00000110077
Uniprot IDs		Q9C0B5	B4DUN6 E9PSA9 Q9H2W1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Benzoyl-CoA Metabolic Process Glycine N-benzoyltransferase Activity Regulation Of Viral Life Cycle Regulation Of Viral Process Glycine N-acyltransferase Activity Nuclear Speck Organization	Positive Regulation Of Protein Localization To Phagocytic Vesicle Postsynaptic Specialization, Intracellular Component Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Pyroptotic Cell Death NLRP3 Inflammasome Complex Assembly Response To Muramyl Dipeptide Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation Canonical Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptotic Inflammatory Response Protein Kinase Activator Activity Regulation Of NLRP3 Inflammasome Complex Assembly