ZDHHC5 and DTX4

Data Source: HiPPIP (Novel)

		ZDHHC5	DTX4
Name		zDHHC palmitoyltransferase 5	deltex E3 ubiquitin ligase 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Plasma Membrane Membrane Dendrite Synapse Phagocytic Vesicle Postsynapse Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Lipid Transport Fatty Acid Transport Protein Palmitoylation Protein Catabolic Process Response To Muramyl Dipeptide Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Protein Maturation Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Localization To Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Phagocytic Vesicle	Notch Signaling Pathway Proteasomal Protein Catabolic Process Protein Ubiquitination Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Innate Immune Response Protein K48-linked Ubiquitination Antiviral Innate Immune Response
Pathways		Maturation of spike protein	IRF3 mediated activation of type 1 IFN Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
GWAS		Anxiety ( 33859377 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General factor of neuroticism ( 30867560 ) Neuroticism ( 29255261 ) Schizophrenia ( 25056061 28991256 29483656 ) Sociability score ( 34054130 ) Worry too long after an embarrassing experience ( 34054130 )	Hepatitis B surface antigen seroclearance in chronic hepatitis B infection ( 29975729 ) Metabolite levels ( 23823483 )
Interacting Genes		1 interacting genes: SRPK2	None recorded
Entrez ID		25921	23220
HPRD ID		15720	19312
Ensembl ID		ENSG00000156599	ENSG00000110042
Uniprot IDs		Q9C0B5	Q9Y2E6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Benzoyl-CoA Metabolic Process Glycine N-benzoyltransferase Activity Regulation Of Viral Life Cycle Regulation Of Viral Process Glycine N-acyltransferase Activity Nuclear Speck Organization	Positive Regulation Of Protein Localization To Phagocytic Vesicle Postsynaptic Specialization, Intracellular Component Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Pyroptotic Cell Death NLRP3 Inflammasome Complex Assembly Response To Muramyl Dipeptide Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation Canonical Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptotic Inflammatory Response Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Plasma Membrane Protein K63-linked Ubiquitination Positive Regulation Of Protein Localization To Cell Periphery Fatty Acid Transport Positive Regulation Of Protein Localization To Membrane Phagocytic Vesicle GABA-ergic Synapse Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Monocarboxylic Acid Transport Acyltransferase Activity Regulation Of Protein Localization To Cell Periphery Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Inflammatory Response Innate Immune Response-activating Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Protein-containing Complex Assembly Activation Of Innate Immune Response Protein Localization To Cell Periphery Postsynapse Intracellular Receptor Signaling Pathway