ZDHHC5 and FAM111A

Data Source: HiPPIP (Novel)

		ZDHHC5	FAM111A
Name		zDHHC palmitoyltransferase 5	FAM111 trypsin like peptidase A
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Plasma Membrane Membrane Dendrite Synapse Phagocytic Vesicle Postsynapse Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	DNA Binding Single-stranded DNA Binding Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Lipid Transport Fatty Acid Transport Protein Palmitoylation Protein Catabolic Process Response To Muramyl Dipeptide Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Protein Maturation Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Localization To Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Phagocytic Vesicle	DNA Replication DNA Repair Proteolysis DNA Damage Response Protein Autoprocessing Replication Fork Processing Negative Regulation Of Viral Genome Replication Protein-DNA Covalent Cross-linking Repair
Pathways		Maturation of spike protein	None
GWAS		Anxiety ( 33859377 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General factor of neuroticism ( 30867560 ) Neuroticism ( 29255261 ) Schizophrenia ( 25056061 28991256 29483656 ) Sociability score ( 34054130 ) Worry too long after an embarrassing experience ( 34054130 )	Heel bone mineral density ( 30598549 )
Interacting Genes		1 interacting genes: SRPK2	None recorded
Entrez ID		25921	63901
HPRD ID		15720	07015
Ensembl ID		ENSG00000156599	ENSG00000166801
Uniprot IDs		Q9C0B5	Q96PZ2
PDB IDs		Not available	8S9K 8S9L
GO Terms Enriched among Interactors		Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Benzoyl-CoA Metabolic Process Glycine N-benzoyltransferase Activity Regulation Of Viral Life Cycle Regulation Of Viral Process Glycine N-acyltransferase Activity Nuclear Speck Organization	Positive Regulation Of Protein Localization To Phagocytic Vesicle Postsynaptic Specialization, Intracellular Component Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Pyroptotic Cell Death NLRP3 Inflammasome Complex Assembly Response To Muramyl Dipeptide Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation Canonical Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptotic Inflammatory Response Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Plasma Membrane Protein K63-linked Ubiquitination Positive Regulation Of Protein Localization To Cell Periphery Fatty Acid Transport Positive Regulation Of Protein Localization To Membrane Phagocytic Vesicle GABA-ergic Synapse Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Monocarboxylic Acid Transport Acyltransferase Activity Regulation Of Protein Localization To Cell Periphery Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Inflammatory Response Innate Immune Response-activating Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Protein-containing Complex Assembly Activation Of Innate Immune Response Protein Localization To Cell Periphery Postsynapse Intracellular Receptor Signaling Pathway