GALK1 and PNRC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GALK1	PNRC2
Description		galactokinase 1	proline rich nuclear receptor coactivator 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	P-body Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Nucleotide Binding Galactokinase Activity Protein Binding ATP Binding Galactose Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor	Protein Binding
	Biological Process	Galactose Metabolic Process Galactitol Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Carbohydrate Phosphorylation Glycolytic Process From Galactose	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		Defective GALK1 causes GALCT2 Galactose catabolism	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester
Diseases		Galactosemia
GWAS		Alanine aminotransferase levels ( 33547301) White blood cell count ( 32888494)	Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: APP FILNC1 PNRC2 SPATA13 SUMO2	23 interacting genes: APP AR BANP DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GALK1 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		2584	55629
HPRD ID		05057	17871
Ensembl ID		ENSG00000108479	ENSG00000189266
Uniprot IDs		P51570 V9HWE7	Q9NPJ4
PDB IDs		1WUU 6GR2 6Q3W 6Q3X 6Q8Z 6Q90 6Q91 6QJE 6ZFH 6ZGV 6ZGW 6ZGX 6ZGY 6ZGZ 6ZH0 7OZX 7RCL 7RCM 7S49 7S4C	4B6H 5KQ1 5KQ4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Presynapse Regulation Of Spontaneous Synaptic Transmission Postsynapse NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Estrogen Response Element Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Steroid Receptor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Zinc Ion Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Developmental Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Transcription Coactivator Binding Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Estrogen Stimulus Regulation Of Cell Differentiation Cellular Response To Lipid
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