GALK1 and SPATA13

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		GALK1	SPATA13
Description		galactokinase 1	spermatogenesis associated 13
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Podosome Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Filopodium Ruffle Membrane Cell Projection Anchoring Junction
	Molecular Function	Nucleotide Binding Galactokinase Activity Protein Binding ATP Binding Galactose Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor	Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Galactose Metabolic Process Galactitol Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Carbohydrate Phosphorylation Glycolytic Process From Galactose	Cell Migration Lamellipodium Assembly Regulation Of Cell Migration Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Defective GALK1 causes GALCT2 Galactose catabolism	CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester
Diseases		Galactosemia
GWAS		Alanine aminotransferase levels ( 33547301) White blood cell count ( 32888494)	Airflow obstruction ( 22837378) Autoimmune thyroid disease ( 32581359) Cerebral cortical growth ( 29682794) Depression and alcohol dependence ( 22064162) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Orofacial clefts ( 22419666) Plateletcrit ( 32888494) Thyroid stimulating hormone levels ( 30367059 32769997) Tumor necrosis factor receptor II (red blood cell fatty acid level interaction) ( 28820441)
Interacting Genes		5 interacting genes: APP FILNC1 PNRC2 SPATA13 SUMO2	3 interacting genes: CDC42 GALK1 KHDRBS1
Entrez ID		2584	221178
HPRD ID		05057	15427
Ensembl ID		ENSG00000108479	ENSG00000182957
Uniprot IDs		P51570 V9HWE7	A0A024RDM6 B4DMC2 E9PFR9 Q96N96
PDB IDs		1WUU 6GR2 6Q3W 6Q3X 6Q8Z 6Q90 6Q91 6QJE 6ZFH 6ZGV 6ZGW 6ZGX 6ZGY 6ZGZ 6ZH0 7OZX 7RCL 7RCM 7S49 7S4C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Presynapse Regulation Of Spontaneous Synaptic Transmission Postsynapse NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion	GBD Domain Binding Storage Vacuole Glycolytic Process From Galactose Galactokinase Activity Galactitol Metabolic Process Grb2-Sos Complex Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway Galactose Binding Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Galactose Catabolic Process Positive Regulation Of RNA Export From Nucleus Leading Edge Membrane Thioesterase Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neuron Fate Determination Establishment Of Golgi Localization Golgi Transport Complex Galactose Metabolic Process Endothelin Receptor Signaling Pathway Phosphotransferase Activity, Alcohol Group As Acceptor Positive Regulation Of Pseudopodium Assembly Golgi Localization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Cardiac Conduction System Development Embryonic Heart Tube Development Dendritic Spine Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Glycolytic Process Through Glucose-6-phosphate Carbohydrate Phosphorylation Glycolytic Process Through Fructose-6-phosphate Poly(U) RNA Binding Regulation Of RNA Export From Nucleus Poly(A) Binding Spindle Midzone Positive Regulation Of Lamellipodium Assembly
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