LRP4 and WHRN

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LRP4	WHRN
Description		LDL receptor related protein 4	whirlin
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Postsynaptic Density Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Plasma Membrane Raft Synapse Synaptic Membrane	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Cilium Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Bundle Stereocilium Tip Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex
	Molecular Function	Calcium Ion Binding Protein Binding Coreceptor Activity Receptor Tyrosine Kinase Binding Apolipoprotein Binding Protein Homodimerization Activity Scaffold Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Kidney Development Hair Follicle Development Endocytosis Enzyme-linked Receptor Protein Signaling Pathway Intracellular Protein Localization Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Ossification Embryonic Limb Morphogenesis Positive Regulation Of Rac Protein Signal Transduction Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Receptor Clustering Generation Of Neurons System Development Dendrite Morphogenesis Negative Regulation Of Axonogenesis Synapse Organization Synaptic Assembly At Neuromuscular Junction Limb Development Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Regulation Of Postsynapse Assembly Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Establishment Of Localization In Cell Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance
Pathways		ECM proteoglycans	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Cenani-Lenz syndactyly syndrome	Deafness, autosomal recessive Usher syndrome (US)
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 19079262) D-dimer levels ( 21502573) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591 30598549) Hip index ( 34021172) Intraocular pressure ( 29617998) Mood instability ( 31168069) Pre-treatment viral load in HIV-1 infection ( 31219150) Reaction time ( 29844566) Systolic blood pressure ( 30224653) Urate levels ( 31578528) Venous thromboembolism ( 31420334)
Interacting Genes		5 interacting genes: DSCR9 DYRK1A LCOR OGT WHRN	17 interacting genes: BEND7 BMI1 CASK COL17A1 EFHC1 GOLGA2 GPSM2 HEMGN KEAP1 LRP4 LRRC4C MYO15A MYO7A PXN RPS6KA1 SPC24 TPRN
Entrez ID		4038	25861
HPRD ID		18517	09718
Ensembl ID		ENSG00000134569	ENSG00000095397
Uniprot IDs		O75096	B9EGE6 Q9P202
PDB IDs		8S9P	1UEZ 1UF1 1UFX 6KZ1 7EP7
Enriched GO Terms of Interacting Partners?		Actin Filament Histone H3T45 Kinase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Circadian Rhythm Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Stereocilia Ankle Link Stereocilia Ankle Link Complex USH2 Complex Periciliary Membrane Compartment Carbon Catabolite Regulation Of Transcription Rhythmic Process Regulation Of Heterochromatin Formation Regulation Of Transcription By Glucose RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Gene Expression Neurofilament NSL Complex Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Stereocilium Bundle	Stereocilium Base Stereocilium Mitotic Spindle Organization Auditory Receptor Cell Stereocilium Organization
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