HAAO

Description		3-hydroxyanthranilate 3,4-dioxygenase
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	3-hydroxyanthranilate 3,4-dioxygenase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	L-tryptophan Catabolic Process NAD+ Biosynthetic Process Response To Zinc Ion Pyridine Nucleotide Biosynthetic Process Quinolinate Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Anthranilate Metabolic Process Dicarboxylic Acid Metabolic Process Response To Cadmium Ion Quinolinate Metabolic Process Neuron Cellular Homeostasis
Pathways		Tryptophan catabolism
Drugs
Diseases
GWAS		Birth weight ( 31043758) Breastfeeding duration ( 25475840) Diastolic blood pressure ( 27841878) Glucose homeostasis traits ( 25524916) Hypospadias ( 25108383) Mean spheric corpuscular volume ( 32888494) Retinitis pigmentosa ( 33514863) Systolic blood pressure ( 27841878 28739976) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		4 interacting genes: ARHGDIA GAD1 POT1 TERF2IP
Entrez ID		23498
HPRD ID		05158
Ensembl ID		ENSG00000162882
Uniprot IDs		P46952
PDB IDs		2QNK 5TK5 5TKQ
Enriched GO Terms of Interacting Partners?		Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Telomere Organization Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Negative Regulation Of DNA Metabolic Process Positive Regulation Of Telomeric Loop Disassembly Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination At Telomere Rho GDP-dissociation Inhibitor Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Chromosome, Telomeric Region Telomeric D-loop Binding Telomere Assembly Regulation Of DNA Repair Single-stranded Telomeric DNA Binding Regulation Of Chromosome Organization Gamma-aminobutyric Acid Biosynthetic Process Succinate Metabolic Process Telomerase Inhibitor Activity Positive Regulation Of DNA Metabolic Process Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane DEAD/H-box RNA Helicase Binding Carbon-carbon Lyase Activity Telomeric D-loop Disassembly Chromosome Organization Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Inhibitory Synapse
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