FUT8 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		FUT8	TTC3
Description		fucosyltransferase 8	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Golgi Cisterna Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding Glycoprotein 6-alpha-L-fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity SH3 Domain Binding Alpha-(1->6)-fucosyltransferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	In Utero Embryonic Development Protein Glycosylation Protein N-linked Glycosylation N-glycan Processing Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Oligosaccharide Biosynthetic Process Regulation Of Gene Expression Fibroblast Migration Cell Migration Protein N-linked Glycosylation Via Asparagine Viral Protein Processing N-glycan Fucosylation L-fucose Catabolic Process Receptor Metabolic Process GDP-L-fucose Metabolic Process Regulation Of Cellular Response To Oxidative Stress	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cirrhosis (alcohol related) ( 32853455) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 29083408) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG monosialylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Ischemic stroke ( 26732560) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Multiple sclerosis--Brain Glutamate Levels ( 20802204) N-glycan levels ( 31163085 21908519 21203500) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio ( 26634245) Red blood cell count ( 32888494) Systemising ( 31508503) Verbal-numerical reasoning ( 27046643)	Eye color traits ( 20463881)
Interacting Genes		3 interacting genes: FBXO7 TTC3 ZBTB10	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		2530	7267
HPRD ID		03994	03773
Ensembl ID		ENSG00000033170	ENSG00000182670
Uniprot IDs		A8K8P8 Q546E0 Q9BYC5	H7BZ57 P53804
PDB IDs		2DE0 6VLD 6VLE 6X5H 6X5R 6X5S 6X5T 6X5U
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Futile Creatine Cycle Lewy Body Core Phosphocreatine Biosynthetic Process Creatine Kinase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Protein Ligase Binding Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Transferase Activity, Transferring Phosphorus-containing Groups	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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