FUT8

Description		fucosyltransferase 8
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Golgi Cisterna Membrane Extracellular Exosome
	Molecular Function	Protein Binding Glycoprotein 6-alpha-L-fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity SH3 Domain Binding Alpha-(1->6)-fucosyltransferase Activity
	Biological Process	In Utero Embryonic Development Protein Glycosylation Protein N-linked Glycosylation N-glycan Processing Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Oligosaccharide Biosynthetic Process Regulation Of Gene Expression Fibroblast Migration Cell Migration Protein N-linked Glycosylation Via Asparagine Viral Protein Processing N-glycan Fucosylation L-fucose Catabolic Process Receptor Metabolic Process GDP-L-fucose Metabolic Process Regulation Of Cellular Response To Oxidative Stress
Pathways		Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cirrhosis (alcohol related) ( 32853455) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 29083408) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG monosialylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Ischemic stroke ( 26732560) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Multiple sclerosis--Brain Glutamate Levels ( 20802204) N-glycan levels ( 31163085 21908519 21203500) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio ( 26634245) Red blood cell count ( 32888494) Systemising ( 31508503) Verbal-numerical reasoning ( 27046643)
Novel Interacting Genes		1 novel interacting genes: CKB
Interacting Genes		3 interacting genes: FBXO7 TTC3 ZBTB10
Entrez ID		2530
HPRD ID		03994
Ensembl ID		ENSG00000033170
Uniprot IDs		A8K8P8 Q546E0 Q9BYC5
PDB IDs		2DE0 6VLD 6VLE 6X5H 6X5R 6X5S 6X5T 6X5U
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Futile Creatine Cycle Lewy Body Core Phosphocreatine Biosynthetic Process Creatine Kinase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Protein Ligase Binding Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Transferase Activity, Transferring Phosphorus-containing Groups
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