FRG1 and GNMT

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FRG1	GNMT
Name		FSHD region gene 1	glycine N-methyltransferase
Structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Nucleolus Cytoplasm Cajal Body Z Disc Striated Muscle Dense Body Catalytic Step 2 Spliceosome	Cytoplasm Cytosol
	Molecular Function	RNA Binding Actin Binding Protein Binding Actin Filament Binding	Protein Binding Folic Acid Binding Methyltransferase Activity Glycine Binding Transferase Activity Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding
	Biological Process	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing Muscle Organ Development RNA Splicing Ribosome Biogenesis	Glycogen Metabolic Process Regulation Of Gluconeogenesis Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process
Pathways		None	Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation Developmental Lineage of Pancreatic Acinar Cells
Drugs		None	Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases		None	Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Brain volume in infants (cerebrospinal fluid) ( 28763065 ) Periodontitis (CDC/AAP) ( 24024966 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 )	Apolipoprotein B levels ( 32203549 ) Blood protein levels ( 30072576 ) LDL cholesterol levels ( 32203549 ) Plasma homocysteine levels (post-methionine load test) ( 24651765 )
Novel Interactors		None recorded	1 novel interactors: STT3B
Interacting Genes		6 interacting genes: CEBPA EXOSC8 GNMT KRT40 LZTS2 RBPMS	31 interacting genes: ADAMTSL4 ARR3 ARRB1 COX7B CTNS DRC12 FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 OTOS PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337
Entrez ID		2483	27232
HPRD ID		03176	05970
Ensembl ID		ENSG00000109536	ENSG00000124713
Uniprot IDs		Q14331	A0A0S2Z5F2 Q14749 V9HW60
PDB IDs		6ZYM 7A5P 8I0W	1R74 2AZT
GO Terms Enriched among Interactors		RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Sarcosine Metabolic Process Glycine N-methyltransferase Activity S-adenosylhomocysteine Metabolic Process Primary Ureteric Bud Growth CHOP-C/EBP Complex U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing White Fat Cell Proliferation Identical Protein Binding MRNA CDS Binding Urea Metabolic Process HMG Box Domain Binding Response To Phenylpropanoid Urea Cycle STAT Family Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation Pre-mRNA Intronic Binding Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Glycine Binding Folic Acid Binding S-adenosylmethionine Metabolic Process Spindle Midzone Assembly Ureter Morphogenesis Microtubule Severing Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process Generation Of Precursor Metabolites And Energy White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Nuclear Exosome (RNase Complex)	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Assembly DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Chromosome Organization Double-stranded Telomeric DNA Binding Positive Regulation Of DNA Metabolic Process G Protein-coupled Receptor Internalization Telomere Maintenance In Response To DNA Damage Positive Regulation Of Organelle Organization Grooming Behavior Chromosome Organization Nuclear Body Positive Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-2 Production Protein Localization To Chromosome Striated Muscle Dense Body Guanine Phosphoribosyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Interleukin-5 Receptor Complex