FRG1

Name	FSHD region gene 1
Structure
Interactors	6 interactors: CEBPA EXOSC8 GNMT KRT40 LZTS2 RBPMS
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Nucleolus Cytoplasm Cajal Body Z Disc Striated Muscle Dense Body Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Actin Binding Protein Binding Actin Filament Binding
	Biological Process	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing Muscle Organ Development RNA Splicing Ribosome Biogenesis
GWAS	Brain volume in infants (cerebrospinal fluid) ( 28763065 ) Periodontitis (CDC/AAP) ( 24024966 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 )
Entrez ID	2483
HPRD ID	03176
Ensembl ID	ENSG00000109536
Uniprot IDs	Q14331
PDB IDs	6ZYM 7A5P 8I0W
GO Terms Enriched among Interactors ?	RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Sarcosine Metabolic Process Glycine N-methyltransferase Activity S-adenosylhomocysteine Metabolic Process Primary Ureteric Bud Growth CHOP-C/EBP Complex U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing White Fat Cell Proliferation Identical Protein Binding MRNA CDS Binding Urea Metabolic Process HMG Box Domain Binding Response To Phenylpropanoid Urea Cycle STAT Family Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation Pre-mRNA Intronic Binding Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Glycine Binding Folic Acid Binding S-adenosylmethionine Metabolic Process Spindle Midzone Assembly Ureter Morphogenesis Microtubule Severing Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process Generation Of Precursor Metabolites And Energy White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Nuclear Exosome (RNase Complex)