FKBP8 and EGLN1

Number of citations of the paper that reports this interaction (PMID 19147576)
10

Data Source:
BioGRID (two hybrid)

		FKBP8	EGLN1
Gene Name		FK506 binding protein 8, 38kDa	egl-9 family hypoxia-inducible factor 1
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Identical Protein Binding Metal Ion Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Apoptotic Process Smoothened Signaling Pathway Regulation Of Gene Expression Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process Chaperone-mediated Protein Folding	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Negative Regulation Of CAMP Catabolic Process Oxygen Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Response To Nitric Oxide
Pathways			Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ARHGEF5 ATP13A2 BCL2 BCL2L1 BNIPL EGFR EGLN1 MAPK14 MTOR PPP3CA PSMC1 PSMD2 RHEB TERF1 VHL	10 interactors: EPAS1 FKBP8 HIF1A HIF3A ING4 KRAS OS9 PLD1 SRC ZNF281
Entrez ID		23770	54583
HPRD ID		05327	06971
Ensembl ID		ENSG00000105701	ENSG00000135766
Uniprot IDs		J3KQ73 Q14318	Q9GZT9 R4SCQ0
PDB IDs		2AWG 2D9F 2F2D 2JWX 3EY6	2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4KBZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Intracellular Signal Transduction Cell Cycle Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Cellular Response To Oxygen Levels Regulation Of Cell Cycle Positive Regulation Of Myotube Differentiation Negative Regulation Of Autophagy Cellular Response To Stress Immune System Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Regulation Of Signaling G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Import Into Nucleus Negative Regulation Of Signaling Cellular Response To Stimulus Response To Stimulus Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Intracellular Transport Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Myotube Differentiation Response To Stress Positive Regulation Of Striated Muscle Cell Differentiation Immune Response-regulating Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of Nucleocytoplasmic Transport Response To Inorganic Substance Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Modification Process	Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Hypoxia Tube Development Response To Stress Cellular Response To Stress Tissue Remodeling Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Nitric-oxide Synthase Activity Response To Abiotic Stimulus Positive Regulation Of Monooxygenase Activity Cellular Response To Stimulus Ras Protein Signal Transduction Regulation Of Gene Expression Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Cell Death Stem Cell Differentiation Signaling Visual Learning Transcription From RNA Polymerase II Promoter Cell Communication Visual Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neural Fold Elevation Formation Regulation Of Transcription, DNA-templated Epithelial Tube Morphogenesis Regulation Of Oxidoreductase Activity Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cell Death Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Associative Learning Regulation Of RNA Metabolic Process Response To Interleukin-1 Response To Oxidative Stress Tube Morphogenesis Epithelium Development Mammary Gland Epithelium Development
Tagcloud ?		e9 exacerbating fibrillary folate folic gfap gliogenesis h3k27me3 lumbar lys27 message msx2 neural neurogenesis neurospheres nkx6 noggin nonresponsive nonresponsiveness o4 olig2 oligodendrocyte oligodendrogenesis tetratricopeptide tube tuj1 ubiquitously utx ventralization	2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Difference) ?		e9 exacerbating fibrillary folate folic gfap gliogenesis h3k27me3 lumbar lys27 message msx2 neural neurogenesis neurospheres nkx6 noggin nonresponsive nonresponsiveness o4 olig2 oligodendrocyte oligodendrogenesis tetratricopeptide tube tuj1 ubiquitously utx ventralization	2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Intersection) ?