CENPU and PLK2

Number of citations of the paper that reports this interaction (PMID 19597481)
29

Data Source:
BioGRID (unspecified method)

		CENPU	PLK2
Gene Name		centromere protein U	polo-like kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Microtubule Organizing Center Cytosol	Intracellular Centrosome Centriole Dendrite
	Molecular Function		Protein Serine/threonine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding Protein Complex Binding
	Biological Process	Mitotic Cell Cycle Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Spindle Organization Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Memory Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long Term Synaptic Depression Negative Regulation Of Dendritic Spine Development
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6	8 interactors: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA
Entrez ID		79682	10769
HPRD ID		14722	06118
Ensembl ID		ENSG00000151725	ENSG00000145632
Uniprot IDs		Q09GN2 Q71F23	Q9NYY3
PDB IDs			4I6H
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis System Development Developmental Process Axon Guidance Nervous System Development Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Cell Differentiation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Locomotion Positive Regulation Of Cellular Protein Catabolic Process Neuron Projection Development Mitotic Cell Cycle Checkpoint Endomembrane System Organization Regulation Of Cellular Protein Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Cell Cycle Cell Part Morphogenesis Mitotic Nuclear Envelope Disassembly Regulation Of Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Movement Of Cell Or Subcellular Component Nuclear Envelope Disassembly Neuron Development Regulation Of Protein Metabolic Process Response To Stimulus Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Cell Cycle Process Cell Morphogenesis Regulation Of Cell Division Spliceosomal Complex Disassembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cytokinesis Neuron Differentiation Cell Projection Organization Nuclear Envelope Organization	Synapse Organization Positive Regulation Of Transport Positive Regulation Of Intracellular Transport Receptor Internalization Negative Regulation Of Microtubule Polymerization Or Depolymerization Neuromuscular Junction Development Nucleotide Phosphorylation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Microtubule Polymerization Or Depolymerization Cell Adhesion Regulation Of Intracellular Transport Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Posttranscriptional Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Receptor Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Transmission Of Virus Development Involved In Symbiotic Interaction Nucleobase-containing Compound Metabolic Process Regulation Of Synapse Structure Or Activity Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Regulation Of Neuron Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Nucleotide Metabolic Process Regulation Of Gene Expression Adult Locomotory Behavior Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell-matrix Adhesion Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Synaptic Growth At Neuromuscular Junction Thrombopoietin-mediated Signaling Pathway Regulation Of Ion Transport Nucleobase-containing Small Molecule Metabolic Process Endocytosis Regulation Of Protein Stability Cell Activation
Tagcloud ?			acts apoptosisassociated bax bgc823 caspase centrosome downregulated elucidated exerted gastric hepatocarcinogenesis inhibiting interfering mitosis mkn45 myeloblastic overexpressed pololike serine sgc7901 si silencing sirnatransfected stages suppressor threonine transfection untransfected vital
Tagcloud (Difference) ?			acts apoptosisassociated bax bgc823 caspase centrosome downregulated elucidated exerted gastric hepatocarcinogenesis inhibiting interfering mitosis mkn45 myeloblastic overexpressed pololike serine sgc7901 si silencing sirnatransfected stages suppressor threonine transfection untransfected vital
Tagcloud (Intersection) ?