ANAPC1 and UBE2S

Number of citations of the paper that reports this interaction (PMID 25306923)
0

Data Source:
BioGRID (pull down)

		ANAPC1	UBE2S
Gene Name		anaphase promoting complex subunit 1	ubiquitin-conjugating enzyme E2S
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Anaphase-promoting Complex Cytoplasm
	Molecular Function		Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	Cellular Protein Modification Process Exit From Mitosis Free Ubiquitin Chain Polymerization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Activation Of Anaphase-promoting Complex Activity Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: ANAPC11 CDC20 CDH1 FBXO5 FZR1 MDC1 UBC UBE2S	29 interactors: ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD FZR1 OTUB1 OTUD7B RBCK1 STAMBP UBA1 UBA6 UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1
Entrez ID		64682	27338
HPRD ID		09769	15603
Ensembl ID		ENSG00000153107	ENSG00000108106
Uniprot IDs		Q9H1A4	Q16763
PDB IDs			1ZDN
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Activation Of Anaphase-promoting Complex Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Cell Cycle Mitotic Nuclear Division Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Meiosis Cell Division Positive Regulation Of Protein Modification Process Protein Polyubiquitination Regulation Of Cell Cycle Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Protein Ubiquitination Regulation Of Cell Division Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Catalytic Activity	Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein K11-linked Ubiquitination Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process Positive Regulation Of Ligase Activity Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Spindle Assembly Checkpoint Regulation Of Protein Ubiquitination Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Spindle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Chromosome Segregation Protein Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Spindle Checkpoint Negative Regulation Of Chromosome Organization Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Modification By Small Protein Removal Protein Ubiquitination Negative Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 racgap1 rel rela relb retinoblastoma route senescent	arising cluster clusters coexpressed coexpression conjugating coregulated endpoints example examples friendly glados guilt http ie kcnk5 messenger modules online outputs potassium powerful subfamily ucd uncovered user weighted wgcna
Tagcloud (Difference) ?		antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 racgap1 rel rela relb retinoblastoma route senescent	arising cluster clusters coexpressed coexpression conjugating coregulated endpoints example examples friendly glados guilt http ie kcnk5 messenger modules online outputs potassium powerful subfamily ucd uncovered user weighted wgcna
Tagcloud (Intersection) ?