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ANAPC1
Gene Name
anaphase promoting complex subunit 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Biological Process
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Pathways
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Bone mineral density (
22504420
)
Obesity-related traits (
23251661
)
Protein-protein Interactions
8 interactors:
ANAPC11
CDC20
CDH1
FBXO5
FZR1
MDC1
UBC
UBE2S
Entrez ID
64682
HPRD ID
09769
Ensembl ID
ENSG00000153107
Uniprot IDs
Q9H1A4
PDB IDs
Enriched GO Terms of Interacting Partners
?
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Activation Of Anaphase-promoting Complex Activity
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Cell Cycle Process
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cell Cycle Checkpoint
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Transferase Activity
Cellular Protein Catabolic Process
Protein K11-linked Ubiquitination
Protein Catabolic Process
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Cell Cycle
Mitotic Nuclear Division
Regulation Of Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Regulation Of Meiosis
Cell Division
Positive Regulation Of Protein Modification Process
Protein Polyubiquitination
Regulation Of Cell Cycle
Regulation Of Meiotic Cell Cycle
Regulation Of Cell Cycle Process
Positive Regulation Of Cellular Protein Metabolic Process
Protein Ubiquitination
Regulation Of Cell Division
Protein Modification By Small Protein Conjugation
Positive Regulation Of Protein Metabolic Process
Regulation Of Proteolysis
Negative Regulation Of Catalytic Activity
Tagcloud
?
antagonizes
canonical
cd40l
cdk6
chip
combine
consequence
crosstalk
dek
ezh2
ikkalpha
involves
kappab2
lymphocytic
microenvironment
nemo
nik
p100
p21waf1
p52
polycomb
psma5
racgap1
rel
rela
relb
retinoblastoma
route
senescent