ANAPC1

Name	anaphase promoting complex subunit 1
Structure
Interactors	12 interactors: CDC20 CDC27 FBXO5 FZR1 HRAS ID2 MDC1 PTTG1 SUMO2 UBC UBE2S WBP2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Molecular Adaptor Activity
	Biological Process	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
GWAS	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic sensitization ( 23817571 ) Asthma ( 30929738 ) Asthma (childhood onset) ( 30929738 ) Corneal endothelial cell density ( 30894546 ) Corneal hysteresis ( 32716492 31246245 30894546 ) Corneal resistance factor ( 32716492 31246245 30894546 ) Femoral neck bone mineral density ( 22504420 ) Heel bone mineral density ( 30598549 ) Hemoglobin levels ( 32327693 ) Intraocular pressure ( 30054594 29785010 ) Obesity-related traits ( 23251661 )
Entrez ID	64682
HPRD ID	09769
Ensembl ID	ENSG00000153107
Uniprot IDs	Q9H1A4
PDB IDs	4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 5LGG 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
GO Terms Enriched among Interactors ?	Anaphase-promoting Complex Binding Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Cell Cycle Cell Division Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Meiotic Nuclear Division Regulation Of Cell Cycle Protein Modification Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Regulation Of Cell Cycle Process Regulation Of Reproductive Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Ubiquitin-protein Transferase Activator Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Negative Regulation Of Cell Cycle Process Protein Polyubiquitination Protein Tag Activity Regulation Of Sister Chromatid Segregation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Positive Regulation Of Post-translational Protein Modification Regulation Of Chromosome Segregation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Negative Regulation Of Cellular Senescence Mitotic Cell Cycle Phase Transition Nucleus