ANAPC1 and FBXO5

Number of citations of the paper that reports this interaction (PMID 16921029)
58

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ANAPC1	FBXO5
Gene Name		anaphase promoting complex subunit 1	F-box protein 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol
	Molecular Function		Protein Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Spindle Assembly Involved In Female Meiosis I Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Vesicle Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Meiotic Nuclear Division Microtubule Polymerization Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Inhibition Of APC-Cdc20 Complex Activity
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	E2F mediated regulation of DNA replication G1/S Transition G1/S-Specific Transcription SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Mitotic Metaphase/Anaphase Transition Phosphorylation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Mitotic G1-G1/S phases M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Obesity-related traits ( 23251661)	Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: ANAPC11 CDC20 CDH1 FBXO5 FZR1 MDC1 UBC UBE2S	16 interactors: ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BTRC CDC16 CDC20 CDC23 CDC27 CDK1 EVI5 FZR1 SKP1 TPM3
Entrez ID		64682	26271
HPRD ID		09769	09348
Ensembl ID		ENSG00000153107	ENSG00000112029
Uniprot IDs		Q9H1A4	Q9UKT4
PDB IDs			2M6N
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Activation Of Anaphase-promoting Complex Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Cell Cycle Mitotic Nuclear Division Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Meiosis Cell Division Positive Regulation Of Protein Modification Process Protein Polyubiquitination Regulation Of Cell Cycle Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Protein Ubiquitination Regulation Of Cell Division Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Catalytic Activity	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Spindle Assembly Checkpoint Positive Regulation Of Proteolysis Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Cell Cycle Checkpoint Regulation Of Chromosome Segregation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Checkpoint Protein Catabolic Process Protein Polyubiquitination Cell Division Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Protein Catabolic Process
Tagcloud ?		antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 racgap1 rel rela relb retinoblastoma route senescent
Tagcloud (Difference) ?		antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 racgap1 rel rela relb retinoblastoma route senescent
Tagcloud (Intersection) ?