RUFY2 and BMX

Number of citations: 0 (PubMedID 11877430)
Data Source: BioGRID (affinity chromatography technology), HPRD (two hybrid, in vivo)

		RUFY2	BMX
Name		RUN and FYVE domain containing 2	BMX non-receptor tyrosine kinase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Ruffle Membrane
	Molecular Function	Protein Binding Zinc Ion Binding SH3 Domain Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Regulation Of Endocytosis	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Protein Autophosphorylation B Cell Receptor Signaling Pathway
Pathways		None	Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs		None	Fostamatinib Zanubrutinib
GWAS		Hip circumference adjusted for BMI ( 34021172 )	No GWAS studies recorded
Interacting Genes		7 interacting genes: BMX DSCAM DUSP23 EPHA3 RAB33A RAB33B SF3B3	26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B
Entrez ID		55680	660
HPRD ID		11526	02111
Ensembl ID		ENSG00000204130	ENSG00000102010
Uniprot IDs		Q5GIA6 Q8WXA3	P51813
PDB IDs		Not available	2EKX 2YS2 3SXR 3SXS 6I99 8X2A
GO Terms Enriched among Interactors		Rab Protein Signal Transduction Neuron Recognition Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Fasciculation Of Motor Neuron Axon Autophagosome Organization Autophagosome Assembly Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Protein Tyrosine Kinase Activity Cell Recognition Fasciculation Of Sensory Neuron Axon	Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Defense Response Positive Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Cell Activation Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation Membrane Raft Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Developmental Process Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Modification Process Regulation Of Epithelial Cell Proliferation Regulation Of Vesicle-mediated Transport Immune System Process Regulation Of Cell Junction Assembly ERBB Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction