PSD4 and LDLRAP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		PSD4	LDLRAP1
Description		pleckstrin and Sec7 domain containing 4	low density lipoprotein receptor adaptor protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cleavage Furrow Ruffle Membrane Cell Projection	Cytoplasm Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Recycling Endosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phospholipid Binding Lipid Binding	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Regulation Of ARF Protein Signal Transduction	Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways			Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance Transport of RCbl within the body
Drugs
Diseases
GWAS		Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Diastolic blood pressure ( 28548082) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Hematocrit ( 27863252 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lymphocyte count ( 32888494) Red blood cell count ( 27863252 32888494) White blood cell count ( 32888494)	Cholesterol, total ( 20686565 24097068 25961943) LDL cholesterol ( 20686565 24097068 25961943) LDL cholesterol levels ( 28334899) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		2 interacting genes: LDLRAP1 USP9X	18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 SNCA TFAP2A
Entrez ID		23550	26119
HPRD ID		15191	05765
Ensembl ID		ENSG00000125637	ENSG00000157978
Uniprot IDs		Q8NDX1	B3KR97 Q5SW96
PDB IDs			2G30
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding K11-linked Deubiquitinase Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Receptor-mediated Endocytosis Involved In Cholesterol Transport Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cytosolic Ciliogenesis Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Intracellular Lipid Transport AP-1 Adaptor Complex Binding Positive Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Import Into Peroxisome Matrix, Receptor Recycling Positive Regulation Of TORC2 Signaling Regulation Of Intracellular Cholesterol Transport AP-2 Adaptor Complex Binding Regulation Of Intracellular Lipid Transport DNA Alkylation Repair Neurofilament Co-SMAD Binding Regulation Of TORC2 Signaling Protein Import Into Peroxisome Matrix Low-density Lipoprotein Particle Clearance Molecular Sequestering Activity Establishment Of Protein Localization To Peroxisome K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Clathrin Adaptor Activity Regulation Of Low-density Lipoprotein Particle Clearance Peroxisomal Membrane Transport Protein K63-linked Deubiquitination Negative Regulation Of Cilium Assembly Receptor Recycling Deubiquitinase Activity Peroxisome Organization Low-density Lipoprotein Particle Receptor Binding Amyloid Precursor Protein Metabolic Process Plasma Lipoprotein Particle Clearance Amyloid Fibril Formation Positive Regulation Of Cholesterol Metabolic Process Intracellular Protein Transmembrane Transport Signaling Receptor Complex Adaptor Activity Clathrin Binding Positive Regulation Of Cholesterol Transport Intracellular Transport Axon Extension Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Binding Receptor Metabolic Process Phosphotyrosine Residue Binding	Clathrin-coated Pit Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Receptor-mediated Endocytosis Negative Regulation Of Transcription By RNA Polymerase II Amyloid-beta Clearance Endocytosis Skeletal System Morphogenesis Vesicle-mediated Transport Positive Regulation Of Lysosomal Protein Catabolic Process Artery Development Clathrin Coat Kidney Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Import Into Cell Negative Regulation Of RNA Metabolic Process Pattern Specification Process Receptor Internalization Anatomical Structure Morphogenesis Regulation Of Lysosomal Protein Catabolic Process Clathrin Adaptor Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Lysosome Low-density Lipoprotein Particle Low-density Lipoprotein Particle Receptor Activity Negative Regulation Of Metabolic Process Regulation Of Amyloid Fibril Formation Regionalization Transcytosis Negative Regulation Of Apoptotic Process Trans-Golgi Network Membrane Clathrin Coat Assembly Regulation Of Neurotransmitter Uptake Negative Regulation Of Programmed Cell Death Developmental Process Endosome Lumen Clathrin-coated Endocytic Vesicle Cellular Response To Copper Ion Regulation Of Receptor Recycling Coronary Vasculature Development Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Synaptic Vesicle
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