PSD4 and USP9X

Number of citations of the paper that reports this interaction (PubMedID 20339350)
34

Data Source:
BioGRID (pull down)

		PSD4	USP9X
Description		pleckstrin and Sec7 domain containing 4	ubiquitin specific peptidase 9 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cleavage Furrow Ruffle Membrane Cell Projection	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phospholipid Binding Lipid Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Regulation Of ARF Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs
Diseases
GWAS		Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Diastolic blood pressure ( 28548082) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Hematocrit ( 27863252 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lymphocyte count ( 32888494) Red blood cell count ( 27863252 32888494) White blood cell count ( 32888494)	Migraine ( 27322543)
Interacting Genes		2 interacting genes: LDLRAP1 USP9X	32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL
Entrez ID		23550	8239
HPRD ID		15191	02091
Ensembl ID		ENSG00000125637	ENSG00000124486
Uniprot IDs		Q8NDX1	A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008
PDB IDs			5VBD 5WCH 7YXX 7YXY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding K11-linked Deubiquitinase Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Receptor-mediated Endocytosis Involved In Cholesterol Transport Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cytosolic Ciliogenesis Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Intracellular Lipid Transport AP-1 Adaptor Complex Binding Positive Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Import Into Peroxisome Matrix, Receptor Recycling Positive Regulation Of TORC2 Signaling Regulation Of Intracellular Cholesterol Transport AP-2 Adaptor Complex Binding Regulation Of Intracellular Lipid Transport DNA Alkylation Repair Neurofilament Co-SMAD Binding Regulation Of TORC2 Signaling Protein Import Into Peroxisome Matrix Low-density Lipoprotein Particle Clearance Molecular Sequestering Activity Establishment Of Protein Localization To Peroxisome K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Clathrin Adaptor Activity Regulation Of Low-density Lipoprotein Particle Clearance Peroxisomal Membrane Transport Protein K63-linked Deubiquitination Negative Regulation Of Cilium Assembly Receptor Recycling Deubiquitinase Activity Peroxisome Organization Low-density Lipoprotein Particle Receptor Binding Amyloid Precursor Protein Metabolic Process Plasma Lipoprotein Particle Clearance Amyloid Fibril Formation Positive Regulation Of Cholesterol Metabolic Process Intracellular Protein Transmembrane Transport Signaling Receptor Complex Adaptor Activity Clathrin Binding Positive Regulation Of Cholesterol Transport Intracellular Transport Axon Extension Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Binding Receptor Metabolic Process Phosphotyrosine Residue Binding	Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration
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