LRRC8B and GBP2

		LRRC8B	GBP2
Description		leucine rich repeat containing 8 VRAC subunit B	guanylate binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding	Nucleotide Binding GTPase Activity Endopeptidase Inhibitor Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity
	Biological Process	Monoatomic Ion Transport Aspartate Transmembrane Transport Monoatomic Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane	Activation Of Innate Immune Response Immune System Process Immune Response Protein Localization To Nucleus Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Symbiont Entry Into Host Cell Defense Response To Gram-positive Bacterium Protein Maturation Defense Response To Virus Cytolysis In Another Organism Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of AIM2 Inflammasome Complex Assembly
Pathways		Miscellaneous transport and binding events	Interferon gamma signaling Interferon alpha/beta signaling CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)	Serum metabolite levels ( 33031748)
Interacting Genes			22 interacting genes: ANXA7 BID BNIP3L BTBD2 CSNK2B FBXO7 FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG
Entrez ID		23507	2634
HPRD ID		18145	02682
Ensembl ID		ENSG00000197147	ENSG00000162645
Uniprot IDs		A0A384N5V6 Q6P9F7	P32456 Q8TCE5
PDB IDs			6VKJ 7E58 7M1S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pyroptotic Inflammatory Response Cytolysis In Another Organism Cytolysis Cellular Response To Interleukin-1 Cellular Response To Type II Interferon Response To Interleukin-1 Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Killing Of Cells Of Another Organism Cellular Response To Lipopolysaccharide Positive Regulation Of Inflammatory Response Positive Regulation Of AIM2 Inflammasome Complex Assembly Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide GTPase Activity Defense Response To Bacterium Defense Response To Virus Taurine Transmembrane Transport Volume-sensitive Anion Channel Activity Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane Response To Molecule Of Bacterial Origin GTP Binding Guanine Nucleotide Transmembrane Transport Response To Virus Cyclic Nucleotide Transport Response To Bacterium Cellular Response To Cytokine Stimulus Regulation Of Inflammatory Response Protein Hexamerization Positive Regulation Of Defense Response Cellular Response To Lipid Response To Cytokine Aspartate Transmembrane Transport Response To Peptide Nucleotide Transmembrane Transport Innate Immune Response Golgi Membrane C4-dicarboxylate Transport Perinuclear Region Of Cytoplasm Protein Homodimerization Activity Defense Response To Protozoan Defense Response To Other Organism Response To Protozoan Molecular Function Inhibitor Activity Defense Response To Symbiont Purine Nucleotide Transport Adenine Nucleotide Transport Purine-containing Compound Transmembrane Transport	Cytoplasm Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Intracellular Signal Transduction Protein Heterodimerization Activity Regulation Of Membrane Permeability Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Assembly Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Organization Mitochondrial Membrane Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Catabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Protein Targeting To Mitochondrion Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Proteolysis Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of JNK Cascade Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Microtubule Anchoring At Centrosome Cytoplasmic Translational Initiation Ribonuclease E Activity Spermidine Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Type II Interferon Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Autophagy Phosphorylation
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