LRRC8B

Description		leucine rich repeat containing 8 VRAC subunit B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Monoatomic Ion Transport Aspartate Transmembrane Transport Monoatomic Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane
Pathways		Miscellaneous transport and binding events
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)
Novel Interacting Genes		3 novel interacting genes: GBP2 GBP3 LRRC8D
Interacting Genes
Entrez ID		23507
HPRD ID		18145
Ensembl ID		ENSG00000197147
Uniprot IDs		A0A384N5V6 Q6P9F7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pyroptotic Inflammatory Response Cytolysis In Another Organism Cytolysis Cellular Response To Interleukin-1 Cellular Response To Type II Interferon Response To Interleukin-1 Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Killing Of Cells Of Another Organism Cellular Response To Lipopolysaccharide Positive Regulation Of Inflammatory Response Positive Regulation Of AIM2 Inflammasome Complex Assembly Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide GTPase Activity Defense Response To Bacterium Defense Response To Virus Taurine Transmembrane Transport Volume-sensitive Anion Channel Activity Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane Response To Molecule Of Bacterial Origin GTP Binding Guanine Nucleotide Transmembrane Transport Response To Virus Cyclic Nucleotide Transport Response To Bacterium Cellular Response To Cytokine Stimulus Regulation Of Inflammatory Response Protein Hexamerization Positive Regulation Of Defense Response Cellular Response To Lipid Response To Cytokine Aspartate Transmembrane Transport Response To Peptide Nucleotide Transmembrane Transport Innate Immune Response Golgi Membrane C4-dicarboxylate Transport Perinuclear Region Of Cytoplasm Protein Homodimerization Activity Defense Response To Protozoan Defense Response To Other Organism Response To Protozoan Molecular Function Inhibitor Activity Defense Response To Symbiont Purine Nucleotide Transport Adenine Nucleotide Transport Purine-containing Compound Transmembrane Transport
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