TNFSF13B and TNFSF13

Number of citations of the paper that reports this interaction (PMID 12370363)
32

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		TNFSF13B	TNFSF13
Gene Name		tumor necrosis factor (ligand) superfamily, member 13b	tumor necrosis factor (ligand) superfamily, member 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Extracellular Space Nucleoplasm Cytoplasm Cytosol External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	B Cell Homeostasis Positive Regulation Of Germinal Center Formation Immune Response Signal Transduction Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of B Cell Proliferation T Cell Costimulation B Cell Costimulation Positive Regulation Of T Cell Proliferation Immunoglobulin Secretion	Immunoglobulin Production In Mucosal Tissue Positive Regulation Of Germinal Center Formation Signal Transduction Positive Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements HuR stabilizes mRNA
Drugs		1,4-Diethylene Dioxide Citric Acid Belimumab
Diseases
GWAS			IgA levels ( 22864923) IgA nephropathy ( 22197929) IgM levels ( 23118916) Non-albumin protein levels ( 22558069)
Protein-Protein Interactions		5 interactors: APP TNFRSF13B TNFRSF13C TNFRSF17 TNFSF13	10 interactors: CAMK1D FAS FURIN SDC2 TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		10673	8741
HPRD ID		04914	05128
Ensembl ID		ENSG00000102524	ENSG00000161955
Uniprot IDs		Q9Y275	B3KR02 O75888 Q2QBA2
PDB IDs		1JH5 1KD7 1KXG 1OQD 1OQE 1OSG 1OTZ 3V56
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Germinal Center Formation Regulation Of Germinal Center Formation Immune System Process B Cell Homeostasis Regulation Of Lymphocyte Activation Regulation Of B Cell Proliferation Regulation Of Cell Activation Lymphocyte Homeostasis Positive Regulation Of B Cell Activation Leukocyte Homeostasis Positive Regulation Of Adaptive Immune Response Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury B Cell Costimulation Regulation Of Adaptive Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Immunoglobulin Production In Mucosal Tissue Homeostasis Of Number Of Cells Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Isotype Switching To IgA Isotypes Axon Choice Point Recognition Regulation Of Immune System Process Positive Regulation Of Cell Activation Homeostatic Process Neuron Remodeling Regulation Of Cell Proliferation Positive Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of B Cell Proliferation Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of Isotype Switching Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mucosal Immune Response Regulation Of Isotype Switching Positive Regulation Of Immune Response Mating Behavior Positive Regulation Of Immunoglobulin Mediated Immune Response Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Positive Regulation Of Immunoglobulin Production Negative Regulation Of B Cell Activation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of B Cell Proliferation Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response	Lymphocyte Homeostasis Leukocyte Homeostasis Signal Transduction Regulation Of Lymphocyte Activation Signaling Negative Regulation Of Lymphocyte Activation Cell Communication Response To Stimulus Regulation Of Cell Activation Negative Regulation Of Leukocyte Activation Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Immune System Process B Cell Homeostasis Negative Regulation Of B Cell Activation Homeostasis Of Number Of Cells Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Organic Substance Regulation Of B Cell Proliferation Immunoglobulin Production Response To Organic Cyclic Compound Extracellular Matrix Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Extracellular Structure Organization Cellular Response To Mechanical Stimulus Negative Regulation Of Immune System Process Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Odontogenesis Of Dentin-containing Tooth T Cell Costimulation Response To External Stimulus Programmed Cell Death Positive Regulation Of Leukocyte Migration Cell Death Death Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Dendrite Development Nerve Growth Factor Production Motor Neuron Apoptotic Process Response To Steroid Hormone Extrinsic Apoptotic Signaling Pathway Regulation Of Leukocyte Migration Immune System Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Response To Tumor Necrosis Factor
Tagcloud ?		17a 23r arntl atf5 ccl20 ccr6 cd40lg ceacam1 covert ctsh cxcr6 faslg furin isg20 ltb map3k4 mcam permissiveness ppargamma pseudotyped ptk2 ptpn13 rorc rosiglitazone serpinb6 th1 th1th17 vsv	aid april bcl2 bcl6 biased capabilities capture decisions deregulation discovered dlbcls ebf1 fusions guides igh immunoglobulin irf8 labor lymphomagenic lymphomas methodologies poised powerful prmd1 readily rearrangements translocations uncover viable
Tagcloud (Difference) ?		17a 23r arntl atf5 ccl20 ccr6 cd40lg ceacam1 covert ctsh cxcr6 faslg furin isg20 ltb map3k4 mcam permissiveness ppargamma pseudotyped ptk2 ptpn13 rorc rosiglitazone serpinb6 th1 th1th17 vsv	aid april bcl2 bcl6 biased capabilities capture decisions deregulation discovered dlbcls ebf1 fusions guides igh immunoglobulin irf8 labor lymphomagenic lymphomas methodologies poised powerful prmd1 readily rearrangements translocations uncover viable
Tagcloud (Intersection) ?