TNFSF13B and TNFRSF13C

Number of citations of the paper that reports this interaction (PubMedID 12721620)
0

Data Source:
HPRD (in vitro, in vivo)

		TNFSF13B	TNFRSF13C
Description		TNF superfamily member 13b	TNF receptor superfamily member 13C
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Signaling Receptor Activity
	Biological Process	B Cell Homeostasis Lymphocyte Homeostasis Transitional One Stage B Cell Differentiation Immune System Process Germinal Center Formation Positive Regulation Of Germinal Center Formation Immune Response Cell Communication Signal Transduction Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation B Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation Skin Development Regulation Of Immune Response	Adaptive Immune Response Immune System Process Positive Regulation Of B Cell Proliferation T Cell Costimulation B Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		1,4-Dioxane Belimumab
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) IgG levels ( 28628107) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Non-albumin protein levels ( 29403010) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Spleen volume ( 34128465) Tonsillectomy ( 28928442 27182965) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 27863252)	Processed meat consumption ( 32066663) Schizophrenia ( 25056061 29483656)
Interacting Genes		5 interacting genes: APP TNFRSF13B TNFRSF13C TNFRSF17 TNFSF13	2 interacting genes: TNFSF13B TRAF3
Entrez ID		10673	115650
HPRD ID		04914	05883
Ensembl ID		ENSG00000102524	ENSG00000159958
Uniprot IDs		A0A0U5J7Q1 Q9Y275	Q5H8V1 Q96RJ3
PDB IDs		1JH5 1KD7 1KXG 1OQD 1OQE 1OSG 3V56 4V46 4ZCH 5Y9J 6FXN	1MPV 1OQE 1OSX 2HFG 3V56 4V46
Enriched GO Terms of Interacting Partners?		Lymphocyte Homeostasis Regulation Of B Cell Proliferation Leukocyte Homeostasis Immune Response Regulation Of B Cell Activation Regulation Of Cell Activation Homeostasis Of Number Of Cells Immune System Process Regulation Of Mononuclear Cell Proliferation Signaling Receptor Activity Regulation Of Leukocyte Proliferation Adaptive Immune Response Positive Regulation Of B Cell Proliferation Positive Regulation Of Cell Activation Tumor Necrosis Factor-mediated Signaling Pathway Homeostatic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Multicellular Organismal-level Homeostasis Regulation Of Lymphocyte Activation Positive Regulation Of B Cell Activation Regulation Of Immune System Process Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cell Surface Receptor Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation B Cell Costimulation Signal Transduction Positive Regulation Of Leukocyte Proliferation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle	Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway B Cell Costimulation Positive Regulation Of Germinal Center Formation Transitional One Stage B Cell Differentiation Cytokine-mediated Signaling Pathway Toll Signaling Pathway Thioesterase Binding CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Germinal Center Formation Regulation Of Germinal Center Formation Immature B Cell Differentiation Positive Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Serine/threonine Protein Kinase Complex Regulation Of Immune Response Positive Regulation Of Immune System Process B Cell Homeostasis Immune Response Cell Surface Toll-like Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway T Cell Costimulation Positive Regulation Of B Cell Proliferation B Cell Proliferation Type I Interferon-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Skin Development MRNA Transcription Regulation Of Defense Response To Virus Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Interferon-beta Production Regulation Of B Cell Proliferation Lymphocyte Homeostasis Antiviral Innate Immune Response Interferon-mediated Signaling Pathway Signaling Adaptor Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process T Cell Proliferation Leukocyte Homeostasis Positive Regulation Of Multicellular Organismal Process Positive Regulation Of B Cell Activation Positive Regulation Of Type I Interferon Production
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