SF3B3 and HSPB1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		SF3B3	HSPB1
Description		splicing factor 3b subunit 3	heat shock protein family B (small) member 1
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GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Proteasome Complex Cornified Envelope Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Contractile Muscle Fiber Extracellular Exosome Axon Cytoplasm
	Molecular Function	Nucleic Acid Binding Protein Binding U2 SnRNA Binding Protein-containing Complex Binding	RNA Binding Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Protein Folding Chaperone Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Regulation Of DNA Repair MRNA Processing RNA Splicing Negative Regulation Of Protein Catabolic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription U2-type Prespliceosome Assembly	Regulation Of Protein Phosphorylation Regulation Of Translational Initiation Protein Folding Response To Unfolded Protein Response To Heat Response To Virus Regulation Of Autophagy Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling
Drugs		Quercetin	Apatorsen Artenimol Phenethyl Isothiocyanate
Diseases			Distal hereditary motor neuropathies (dHMN)
GWAS		Brain morphology (MOSTest) ( 32665545) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Schizophrenia ( 30285260)
Interacting Genes		108 interacting genes: APBB1 EFTUD2 EIF4ENIF1 EPS8 ERCC6 ERG HCK HGS HSPB1 KIF13B KLF10 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MPP3 NAGK NOL12 OSGEP PPIL1 PRKN PRPF40A RAD9A RBFOX2 RBM6 RNF10 RUFY2 SF3B1 SMAD5 SNRNP200 SREK1 TAF9 TCERG1 TOE1 U2AF2 USP7 WBP4 WWOX YWHAG ZNF579	248 interacting genes: ACAP2 ACBD6 ACTC1 ACTN1 ACTN2 ACTN4 ADCY9 ADD3 ADPRS AGAP10P AGAP3 AGAP4 AGAP5 AGAP7P AKT1 ALPI AMD1 ANAPC7 ANK1 ANKRD7 ANXA1 AP2B1 APPL1 ARHGAP28 ARHGEF7 ARIH1 ARRDC5 ATXN10 BICDL1 C11orf98 CAMK1 CBX1 CCDC32 CCDC70 CCHCR1 CCNC CCNDBP1 CCNO CDK5RAP3 CENPK CEP78 CETN3 CFAP251 CIMIP6 CLCN3 CPSF3 CRNKL1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX DCPH1 DES DMAP1 DNAJC21 ECPAS EHD1 EIF1AX EIF2S1 EIF3M EIF4G1 EIF4G3 EIF5 ENPP2 EPB41L1 EPB41L2 EPB41L3 ERCC5 ERICH6 ESR1 FLNB FNDC3B FOXP1 FXR1 FXR2 GAPVD1 GARIN2 GDI2 GLMN GNPAT GOLGA8A GRIPAP1 GRK3 GSTO1 GTSF1 GUCA1A HAUS8 HDLBP HNRNPD HNRNPU HSP90AB1 HSPA4 HSPB8 IARS2 IGBP1 IGSF21 INPP5K INS ISG20L2 KANSL1 KCMF1 KCTD3 KLC1 KNSTRN KPNA3 KRT18 KRT72 LBP LIG1 LONRF1 LRIF1 LSM3 LUZP1 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MCM6 MDH2 MED31 MFAP1 MPHOSPH6 MRGBP MRPL28 MRPL40 MRPS23 MSL1 MTIF2 MYG1 MYL12A MYL12B MYL9 MYLK NAP1L1 NAPA NBAS NCKIPSD NEK10 NEXN NFKBIA NFU1 NSMCE4A NVL OBSL1 OPTN OSBPL9 PAF1 PALM3 PELO PGM2 PHYHIPL PLG PNISR PNPT1 POP7 POPDC1 PPA1 PPM1A PPP2R3C PRPF19 PRPF40A PSMA3 PSMA6 PSMB2 PSMC1 PSMD1 PTGES3 PTPN3 PTPRA RAB41 RAD23A RALA RASSF9 RBM25 RBM48 RBPJ RPAP3 RPSA RSPH3 RYBP S100A4 SAT1 SBF1 SEC13 SERTAD1 SF3A3 SF3B3 SLC26A4-AS1 SLC7A9 SLC9D1 SMARCA2 SMARCA4 SMARCD1 SNRNP200 SNRPF SPACA7 SPATA7 SPIN1 SPTBN1 SRP72 STUB1 SUMO2 SUPT5H SYCE1 TARBP2 TARS1 TBC1D1 TBC1D3B TGFB1I1 TGM1 THOC5 TJP2 TOMM70 TOX4 TP53 TPT1 TRIM24 TRIM54 TRIM63 TSNAXIP1 TTC3 TTC39C TXNL1 UCHL5 UFD1 UQCC2 UQCRB VIM WASHC3 WDR83 WEE2-AS1 WWP1 XPO1 XRCC5 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB17 ZBTB37 ZFAT ZNF131 ZNF197 ZNRF3
Entrez ID		23450	3315
HPRD ID		12027	09076
Ensembl ID		ENSG00000189091	ENSG00000106211
Uniprot IDs		A8K6V3 Q15393	P04792 V9HW43
PDB IDs		5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6AHD 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7KTS 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8H7G 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E	2N3J 3Q9P 3Q9Q 4MJH 6DV5 6GJH
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Positive Regulation Of MRNA Catabolic Process RNA Destabilization Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Regulation Of Translation Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Cytosol RNA Binding Cytoplasm Nucleus Z Disc Nucleoplasm Translational Initiation Protein-RNA Complex Assembly Proteasome Complex Cytoskeletal Protein Binding Catalytic Step 2 Spliceosome Translation Initiation Factor Activity Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Structural Constituent Of Eye Lens Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Component Assembly Nuclear Matrix Positive Regulation Of Metabolic Process Intracellular Protein Localization Regulation Of Cellular Localization Protein-containing Complex Organization M Band Regulation Of Telomere Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Heat Regulation Of Intracellular Transport Cellular Response To Topologically Incorrect Protein Focal Adhesion Positive Regulation Of RNA Metabolic Process Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Calcium-dependent Protein Serine/threonine Kinase Activity Protein Localization To Organelle Regulation Of Chromosome Organization Glutamatergic Synapse Regulation Of Cell Cycle Spliceosomal Complex MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome Protein Folding Chaperone Complex Positive Regulation Of Translation Stress-induced Premature Senescence Myosin Heavy Chain Binding Organelle Organization Identical Protein Binding
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