SPECC1L and ELOA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPECC1L	ELOA
Description		sperm antigen with calponin homology and coiled-coil domains 1 like	elongin A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Spindle Cytoskeleton Cell-cell Junction Gap Junction Actin Cytoskeleton Microtubule Cytoskeleton Filamentous Actin Anchoring Junction	Extracellular Space Nucleus Nucleoplasm Elongin Complex Site Of DNA Damage
	Molecular Function	Protein Binding Beta-catenin Binding	Protein Binding
	Biological Process	Negative Regulation Of Microtubule Depolymerization Cell Adhesion Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Depolymerization Adherens Junction Organization Neural Crest Cell Delamination Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Anterior Neural Tube Closure	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Caffeine consumption from tea ( 33287642) Coronary artery disease ( 29212778 32469254) Kawasaki disease ( 33692975) Mean reticulocyte volume ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		11 interacting genes: APC ECPAS EFCAB3 ELOA GLIS2 PPP1R12C SNW1 UBC UBE2I ZFHX3 ZNF250	58 interacting genes: AXIN2 BACH2 BRCA1 CBY2 CCDC57 CDR2L CEP57L1 CEP70 CNTROB CUL5 DLGAP1-AS2 ELOB ERCC6 EVI5 FAM9B FCHO1 FXR1 GMCL1 GOLGA6A GRIPAP1 HIVEP1 HOMEZ JAKMIP2 KANK2 KLHL2 KRT40 KRTAP10-3 KXD1 LMNA LZTS1 MCC MDFI MED21 MID1 MID2 NAB2 NACC1 NAF1 NFKBID NINL OGT PER2 PLK4 PPFIA1 PRDM6 PRMT5 RABEP1 RAD54B RAP1A REXO1 RNF10 SIRPA SPECC1L TNIP1 TP53BP2 TRIM37 TRIM54 ZNF792
Entrez ID		23384	6924
HPRD ID		11080	02873
Ensembl ID		ENSG00000100014	ENSG00000011007
Uniprot IDs		B2RMV2 Q69YQ0	Q14241
PDB IDs			4HFX 6ZUZ 8OEV 8OEW 8OF0
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Cytoskeleton Organization Identical Protein Binding Regulation Of Organelle Organization Regulation Of Microtubule-based Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Negative Regulation Of RNA Metabolic Process Regulation Of Cytoskeleton Organization Microtubule-based Process Centriole Replication Regulation Of Centriole Replication Regulation Of Protein Localization To Synapse Nuclear Pore Localization Regulation Of Receptor Localization To Synapse Centriole Assembly Negative Regulation Of Microtubule Depolymerization Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Activity Microtubule Organizing Center Organization Negative Regulation Of Supramolecular Fiber Organization Protein Ubiquitination Negative Regulation Of Centriole Replication Regulation Of Microtubule Depolymerization Cytoplasm Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Centrosome Duplication Protein Binding Negative Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Protein Localization To Microtubule Cytoskeleton XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cul5-RING Ubiquitin Ligase Complex Regulation Of RNA Metabolic Process
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