CRTC1 and TBK1

Number of citations of the paper that reports this interaction (PubMedID 33411856)
125

Data Source:
BioGRID (enzymatic study)

		CRTC1	TBK1
Description		CREB regulated transcription coactivator 1	TANK binding kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body	Nucleoplasm Cytoplasm Cytosol Serine/threonine Protein Kinase Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Memory Positive Regulation Of CREB Transcription Factor Activity Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Homotetramerization Cellular Response To CAMP Energy Homeostasis Negative Regulation Of Membrane Hyperpolarization	Cytoplasmic Translation Activation Of Innate Immune Response Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Phosphorylation Protein Import Into Nucleus Inflammatory Response Canonical NF-kappaB Signal Transduction MRNA Transcription Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Macroautophagy Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway TORC1 Signaling TORC2 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway T Follicular Helper Cell Differentiation Defense Response To Other Organism Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling
Pathways		Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs			Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 32918910 27527254) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Body fat percentage ( 26833246) Body mass index ( 28448500 28552196) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Esophageal adenocarcinoma ( 24121790) Estimated glomerular filtration rate ( 31152163) Gastroesophageal reflux disease ( 31527586 34187846) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Menarche (age at onset) ( 21102462 25231870) Walking pace ( 33128006)	Amyotrophic lateral sclerosis ( 27455348 29566793) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung adenocarcinoma ( 28604730) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		5 interacting genes: CREB1 MAP3K1 SRPK2 TBK1 YWHAG	47 interacting genes: AGO2 APP ATG9A AZI2 CDC20 CDC37 CDC42BPG CRTC1 CYLD FZR1 HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 LMO7 MAVS MBP MIB2 MTPAP NCK1 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SIKE1 SMCR8 SMURF1 STX11 TANK TICAM1 TNIP1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TXLNG UBC UBQLN2 VHL XIAP
Entrez ID		23373	29110
HPRD ID		06339	05322
Ensembl ID		ENSG00000105662	ENSG00000183735
Uniprot IDs		Q6UUV9	Q9UHD2
PDB IDs		7D8H 7D8P 7D9V	4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B 6RSR 6RST 6RSU
Enriched GO Terms of Interacting Partners?		Protein Modification Process Protein Phosphorylation Phosphorylation Protein Metabolic Process Intracellular Signal Transduction Intracellular Signaling Cassette Phosphoprotein Binding Peptidyl-serine Phosphorylation Positive Regulation Of Translational Initiation MRNA Transcription Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Chemotaxis To Arachidonate TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Modulation Of Chemical Synaptic Transmission Phosphate-containing Compound Metabolic Process Macromolecule Metabolic Process Protein Kinase Activity Regulation Of TORC1 Signaling Regulation Of Translational Initiation Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production Cytoplasmic Translation MRNA Metabolic Process Kinase Activity Response To Dehydroepiandrosterone Regulation Of Immune System Process Response To Stress Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein Kinase C Inhibitor Activity Dendritic Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of TOR Signaling Positive Regulation Of Translation ATF4-CREB1 Transcription Factor Complex Response To Hypobaric Hypoxia Trans-synaptic Signaling By BDNF Nuclear Speck Organization Cellular Response To Peptide Hormone Stimulus Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly	Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Metabolic Process Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Activation Of Immune Response Immune Response-activating Signaling Pathway Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Regulation Of Cell Communication Positive Regulation Of Type I Interferon Production Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Interferon-beta Production Response To Virus Tumor Necrosis Factor-mediated Signaling Pathway Response To External Biotic Stimulus Cytosol Immune Response-regulating Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Other Organism Regulation Of Immune System Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Immune Response Signaling Adaptor Activity Cytoplasm Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Protein Ubiquitination
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