CRTC1 and MAP3K1

Number of citations of the paper that reports this interaction (PMID 18784253)
6

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CRTC1	MAP3K1
Gene Name		CREB regulated transcription coactivator 1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane	Cytosol
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding JUN Kinase Kinase Activity Protein Kinase Binding
	Biological Process	Transcription, DNA-templated Memory Viral Process Positive Regulation Of CREB Transcription Factor Activity Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Protein Homotetramerization Membrane Hyperpolarization	Activation Of MAPKK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Epithelial Cell Morphogenesis Protein Phosphorylation Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of JUN Kinase Activity Apoptotic Mitochondrial Changes Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Wound Healing Innate Immune Response Eyelid Development In Camera-type Eye Cellular Response To Mechanical Stimulus
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462)	Breast cancer ( 17529967 23535729 20453838 19330030) Triglycerides ( 20686565) Type 2 diabetes ( 23209189)
Protein-Protein Interactions		3 interactors: CREB1 MAP3K1 YWHAG	30 interactors: ACTN1 ARHGAP4 BRCA1 CHUK CRTC1 DCAF7 DTX1 GRB2 GSK3B IKBKB JUN MAP2K4 MAP2K7 MAPK1 MAPK3 MAPK8 MAPK9 NFKBIA NR4A1 PAK1 RAF1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L6 UBE2W YWHAE
Entrez ID		23373	4214
HPRD ID		06339	19599
Ensembl ID		ENSG00000105662	ENSG00000095015
Uniprot IDs		Q6UUV9	Q13233
PDB IDs
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Fc-epsilon Receptor Signaling Pathway MAPK Cascade Regulation Of Innate Immune Response Fc Receptor Signaling Pathway Signal Transduction By Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Component Size Immune Response-regulating Cell Surface Receptor Signaling Pathway Mitochondrion Organization Positive Regulation Of Organelle Organization Regulation Of Catalytic Activity Response To Peptide Hormone Negative Regulation Of Transcription By Competitive Promoter Binding Immune Response-regulating Signaling Pathway Response To Peptide Response To Organic Substance Epithelial Cell Differentiation Lung Saccule Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Zinc Ion Type I Pneumocyte Differentiation Positive Regulation Of Immune Response Eyelid Development In Camera-type Eye Regulation Of Signaling Organelle Organization Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Osteoclast Differentiation Cell Differentiation Regulation Of Kinase Activity Innate Immune Response	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Fc Receptor Signaling Pathway Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Cellular Response To Organic Substance Toll-like Receptor 10 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response Regulation Of Immune System Process Response To Abiotic Stimulus Response To Organic Substance Defense Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Response To Stress Positive Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Stress Immune System Process Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		adeno appsw braak coactivator creb decline deficits dephosphorylation deregulation efficiently elucidate examining hippocampus impairments ind learning memory microarrays neurotransmission pathological plasticity restoring reverses ser151 spatial stages synaptic transcriptome transcriptomic	5q11 alleles ancestry attempt biologically coincided composing consortium gata3 gwass ichav1 ichav2 ichav2a ichav3 looping minor pcond prioritized ptrend rs113317823 rs11949391 rs16886397 rs17432750 rs62355900 rs62355902 rs74345699 rs889312 strongest variants
Tagcloud (Difference) ?		adeno appsw braak coactivator creb decline deficits dephosphorylation deregulation efficiently elucidate examining hippocampus impairments ind learning memory microarrays neurotransmission pathological plasticity restoring reverses ser151 spatial stages synaptic transcriptome transcriptomic	5q11 alleles ancestry attempt biologically coincided composing consortium gata3 gwass ichav1 ichav2 ichav2a ichav3 looping minor pcond prioritized ptrend rs113317823 rs11949391 rs16886397 rs17432750 rs62355900 rs62355902 rs74345699 rs889312 strongest variants
Tagcloud (Intersection) ?