NUFIP1 and GEMIN6

Number of citations of the paper that reports this interaction (PubMedID 26275778)
67

Data Source:
BioGRID (two hybrid, pull down, imaging technique)

		NUFIP1	GEMIN6
Description		nuclear FMR1 interacting protein 1	gem nuclear organelle associated protein 6
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Transcription Elongation Factor Complex Nuclear Matrix Protein-containing Complex Synapse Presynaptic Active Zone Pre-snoRNP Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding SnoRNA Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding ATPase Binding	RNA Binding Protein Binding
	Biological Process	Box C/D SnoRNP Assembly RNA Processing Positive Regulation Of Transcription By RNA Polymerase II	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Body mass index ( 25760438) HDL cholesterol levels ( 32203549) Oleic acid (18:1n-9) levels ( 23362303) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		12 interacting genes: BRCA1 CCNT1 DDX20 FMR1 GEMIN2 GEMIN4 GEMIN6 KLF6 OGT SNU13 TAF9 TTC3	16 interacting genes: ACOT11 DDIT4L GEMIN7 NUFIP1 RASL11B RN7SL1 RNU1-1 RNU2-1 SNRPB SNRPD2 SNRPD3 SNRPE SNRPF SNRPG STRAP TOX4
Entrez ID		26747	79833
HPRD ID		05073	06110
Ensembl ID		ENSG00000083635	ENSG00000152147
Uniprot IDs		Q9UHK0	Q8WXD5
PDB IDs		5L85	1Y96 7BBL
Enriched GO Terms of Interacting Partners?		SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly Nucleoplasm MRNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process RNA Metabolic Process Nucleolus Nuclear Body Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nucleus Macromolecule Metabolic Process RNA Processing Protein-containing Complex Organization Box C/D SnoRNP Assembly Cellular Component Assembly RNA Polymerase Binding DNA-binding Transcription Factor Binding Regulation Of Lipid Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Spliceosomal Complex Assembly Molecular Condensate Scaffold Activity Transcription Cis-regulatory Region Binding Positive Regulation Of Intracellular Transport Of Viral Material Box C/D Sno(s)RNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cajal Body Positive Regulation Of Transcription By RNA Polymerase II P53 Binding Regulation Of Lipid Metabolic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Host-mediated Perturbation Of Viral Process P-TEFb Complex Dendritic Filopodium Histone H3 Reader Activity U4atac SnRNP Dense Fibrillar Component	SMN-Sm Protein Complex 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly U2 SnRNP U4 SnRNP Methylosome Protein-RNA Complex Assembly Small Nuclear Ribonucleoprotein Complex U1 SnRNP U7 SnRNP U5 SnRNP U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions PICln-Sm Protein Complex RNA Methylation Catalytic Step 2 Spliceosome RNA Splicing Macromolecule Methylation Protein-containing Complex Assembly MRNA Processing Precatalytic Spliceosome Protein-containing Complex Organization RNA Modification Spliceosomal Complex RNA Processing Methylation MRNA Metabolic Process Ribonucleoprotein Complex U2 SnRNP Binding Cellular Component Assembly Telomerase Holoenzyme Complex RNA Metabolic Process RNA Binding Histone Pre-mRNA DCP Binding Spliceosomal Tri-snRNP Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process SMN Complex U2-type Prespliceosome Telomerase RNA Binding Protein Methylation Pre-mRNA Branch Point Binding MRNA Branch Site Recognition
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