SMG6 and PPP1CC

Number of citations of the paper that reports this interaction (PMID 21382349)
13

Data Source:
BioGRID (two hybrid)

		SMG6	PPP1CC
Gene Name		SMG6 nonsense mediated mRNA decay factor	protein phosphatase 1, catalytic subunit, gamma isozyme
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein Complex MLL5-L Complex PTW/PP1 Phosphatase Complex
	Molecular Function	Endoribonuclease Activity Protein Binding Telomeric DNA Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Telomere Maintenance MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Mitotic Cell Cycle Glycogen Metabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Loss of Function of TGFBR2 in Cancer Mitotic Prometaphase Metabolism of lipids and lipoproteins Separation of Sister Chromatids Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Mitotic Anaphase TGFBR1 LBD Mutants in Cancer M Phase Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase SMAD4 MH2 Domain Mutants in Cancer
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID Motuporin
Diseases
GWAS		Aortic root size ( 19584346) Bone mineral density ( 22504420) Coronary heart disease ( 21378990) Esophageal cancer (squamous cell) ( 22960999) Metabolite levels (5-HIAA) ( 23319000)	Heart rate ( 23583979)
Protein-Protein Interactions		3 interactors: PPP1CC SMG5 TERT	114 interactors: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C11orf74 C15orf59 C1QA C9orf50 CD2BP2 CLMN CLTC CNST COPS5 CSNK1A1 CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DYRK4 EIF2AK2 ELP4 ENKD1 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IL3RA JAK2 KCTD20 KDM4D KIAA1377 KRCC1 LMTK2 MAP4K4 MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 PPP1R13B PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R32 PPP1R35 PPP1R3C PPP1R3D PPP1R8 PPP1R9B PRR16 RAF1 RB1 RIF1 RNF19B RPL7 RPRD2 RRM1 RRP1B SDR39U1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 TACC2 TBC1D19 TCTEX1D4 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A TWISTNB VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF667
Entrez ID		23293	5501
HPRD ID		06502	08911
Ensembl ID		ENSG00000070366	ENSG00000186298
Uniprot IDs		Q86US8	P36873
PDB IDs		2DOK 2HWW 2HWX	1IT6 1JK7 1U32 2BCD 2BDX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Telomere Formation Via Telomerase Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Telomere Assembly Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference RNA Interference Replicative Senescence Triglyceride Catabolic Process RNA-dependent DNA Replication Regulation Of Gene Silencing Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Cellular Response To DsRNA Posttranscriptional Gene Silencing Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Glycogen Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Gene Silencing By RNA MRNA Export From Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Response To DsRNA RNA Export From Nucleus Telomere Maintenance Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Triglyceride Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Circadian Rhythm Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Nuclear Export MRNA Transport Regulation Of Dephosphorylation Catabolic Process	Regulation Of Dephosphorylation Regulation Of Phosphatase Activity Regulation Of Phosphorus Metabolic Process Gene Expression Negative Regulation Of Phosphatase Activity RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Dephosphorylation RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Aromatic Compound Metabolic Process Nervous System Development Regulation Of Catalytic Activity Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hydrolase Activity Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromatin Organization Neurogenesis Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Generation Of Neurons Chromosome Organization Regulation Of Gene Expression Neuron Apoptotic Process Cellular Localization Response To Radiation Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of Cellular Metabolic Process Cell Cycle Neuron Death Apoptotic Process Chromatin Modification Spindle Organization Cellular Protein Modification Process Histone Modification Neuron Differentiation Cellular Component Assembly Programmed Cell Death Transcription From RNA Polymerase II Promoter
Tagcloud ?		atf atf6 caenorhabditis counteracts elegans exos exosome f48e8 folding fundamental ire ire1 larval lethality maintains metazoans misfolded neurologic nmd nonsense ok275 pek sensitize tm1153 transducers upr v33 worms	3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		atf atf6 caenorhabditis counteracts elegans exos exosome f48e8 folding fundamental ire ire1 larval lethality maintains metazoans misfolded neurologic nmd nonsense ok275 pek sensitize tm1153 transducers upr v33 worms	3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?