SMG6

Gene Name		SMG6 nonsense mediated mRNA decay factor
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Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex
	Molecular Function	Endoribonuclease Activity Protein Binding Telomeric DNA Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Telomere Maintenance MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Bone mineral density ( 22504420) Coronary heart disease ( 21378990) Esophageal cancer (squamous cell) ( 22960999) Metabolite levels (5-HIAA) ( 23319000)
Protein-protein Interactions		3 interactors: PPP1CC SMG5 TERT
Entrez ID		23293
HPRD ID		06502
Ensembl ID		ENSG00000070366
Uniprot IDs		Q86US8
PDB IDs		2DOK 2HWW 2HWX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Telomere Formation Via Telomerase Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Telomere Assembly Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference RNA Interference Replicative Senescence Triglyceride Catabolic Process RNA-dependent DNA Replication Regulation Of Gene Silencing Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Cellular Response To DsRNA Posttranscriptional Gene Silencing Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Glycogen Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Gene Silencing By RNA MRNA Export From Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Response To DsRNA RNA Export From Nucleus Telomere Maintenance Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Triglyceride Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Circadian Rhythm Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Nuclear Export MRNA Transport Regulation Of Dephosphorylation Catabolic Process
Tagcloud ?		atf atf6 caenorhabditis counteracts elegans exos exosome f48e8 folding fundamental ire ire1 larval lethality maintains metazoans misfolded neurologic nmd nonsense ok275 pek sensitize tm1153 transducers upr v33 worms