FMO3 and SGSM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FMO3	SGSM3
Description		flavin containing dimethylaniline monoxygenase 3	small G protein signaling modulator 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Gap Junction
	Molecular Function	Monooxygenase Activity N,N-dimethylaniline Monooxygenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Trimethylamine Monooxygenase Activity Albendazole Monooxygenase Activity Hypotaurine Monooxygenase Activity Flavin Adenine Dinucleotide Binding NADP Binding	GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Taurine Biosynthetic Process	Endosomal Transport Regulation Of Endocytosis Regulation Of Rab Protein Signal Transduction Rap Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Protein Catabolic Process Plasma Membrane To Endosome Transport Regulation Of Cell Cycle Regulation Of Cilium Assembly
Pathways		FMO oxidises nucleophiles Defective FMO3 causes TMAU
Drugs
Diseases
GWAS		Lentiform nucleus volume ( 22903471) Serum metabolite levels ( 33031748)	Body mass index ( 26426971) Breast size ( 29855537) Chronotype ( 27494321) Height ( 19570815) Mammographic density (dense area) ( 25342443) Morning vs. evening chronotype ( 27494321) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		4 interacting genes: CLEC10A CREB3 SACM1L SGSM3	10 interacting genes: CHRM3 DSCAM FMO3 GJA1 NF2 RAB39B RAB5A RAB5B RAB5C RPL35
Entrez ID		2328	27352
HPRD ID		00633	15285
Ensembl ID		ENSG00000007933	ENSG00000100359
Uniprot IDs		A0A024R8Z4 B7Z3M2 B7Z543 P31513 Q53FW5	B4DVE3 B9A6J5 Q96HU1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deacetylase Activity	Plasma Membrane To Endosome Transport G Protein Activity GDP Binding Endocytic Vesicle Early Endosome GTPase Activity Melanosome GTP Binding Regulation Of Transport Membrane Cell Junction Organization Regulation Of Vesicle-mediated Transport Early Endosome Membrane Endomembrane System Endosomal Transport Plasma Membrane Albendazole Monooxygenase Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Cellular Component Organization Netrin Receptor Binding Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Regulation Of Stem Cell Proliferation Endosome Organization Positive Regulation Of Mesodermal Cell Differentiation Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Schwann Cell Proliferation Ruffle Protein Localization To Early Endosome Intracellular Protein Localization Endocytosis Dendrite N,N-dimethylaniline Monooxygenase Activity Taurine Biosynthetic Process Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Cytoplasmic Side Of Early Endosome Membrane Protein Transport Synaptic Vesicle Membrane G Protein-coupled Acetylcholine Receptor Activity Gap Junction Hemi-channel Activity Vesicle-mediated Transport Intracellular Protein Transport Saliva Secretion Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Secretion By Cell Acetylcholine Binding Cell-cell Signaling Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway
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