ANKRD12 and HIF1AN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ANKRD12	HIF1AN
Description		ankyrin repeat domain 12	hypoxia inducible factor 1 subunit alpha inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function		Transcription Corepressor Activity Notch Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity [protein]-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Metal Ion Binding NF-kappaB Binding Dioxygenase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-aspartic Acid 3-dioxygenase Activity Ankyrin Repeat Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Vasculogenesis
Pathways			Cellular response to hypoxia
Drugs			D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases
GWAS		Emphysema imaging phenotypes ( 26030696) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293)
Interacting Genes		8 interacting genes: CDK4 CDK6 CDKN2A HDAC3 HIF1AN MEOX2 MTNR1A TADA3	17 interacting genes: ANKRD12 ANKRD37 ANKRD50 ASB13 ASB4 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL
Entrez ID		23253	55662
HPRD ID		12457	09426
Ensembl ID		ENSG00000101745	ENSG00000166135
Uniprot IDs		Q6UB98	Q9NWT6
PDB IDs			1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6 6RUJ 7A1J 7A1K 7A1L 7A1M 7A1N 7A1O 7A1P 7A1Q 7A1S 8IHZ 8II0 8K71 8K72 8K73 9FSN 9IIF
Enriched GO Terms of Interacting Partners?		Cyclin Binding NF-kappaB Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Export From Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK6 Complex Ligase Inhibitor Activity Positive Regulation Of Ferroptosis [protein]-asparagine 3-dioxygenase Activity Regulation Of Epithelial Cell Proliferation Regulation Of Protein Stability Cell Cycle G1/S Phase Transition Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Fibroblast Proliferation Cell Division Regulation Of Gene Expression Cyclin D1-CDK4 Complex Regulation Of Cell Cycle Phase Transition Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Positive Regulation Of Protein Localization To Nucleus Protein De-2-hydroxyisobutyrylase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin D2-CDK4 Complex Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Hemopoiesis Positive Regulation Of Macrophage Apoptotic Process Regulation Of Nucleocytoplasmic Transport Apoptotic Process Involved In Mammary Gland Involution Protein Lysine Delactylase Activity	Protein Lysine Delactylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity NF-kappaB Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Protein De-2-hydroxyisobutyrylase Activity Enzyme Binding Fungiform Papilla Formation Protein Modification Process Histone Deacetylase Binding Hair Follicle Placode Formation Histone Deacetylase Complex Transcription Corepressor Binding Cytosol DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Deacetylase Activity P53 Binding Protein Deacetylation Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Cul5-RING Ubiquitin Ligase Complex NuRD Complex Protein Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Negative Regulation Of Signal Transduction Regulation Of Cell Fate Specification Regulation Of Apoptotic Process Protein Ubiquitination Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Circadian Rhythm Regulation Of Programmed Cell Death Heterochromatin Formation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Amyloid Fibril Formation Regulation Of TOR Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Glial Cell Differentiation Nucleosomal DNA Binding Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Intracellular Signal Transduction
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