VEGFC

Description		vascular endothelial growth factor C
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Growth Factor Activity Chemoattractant Activity Vascular Endothelial Growth Factor Receptor 3 Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Response To Hypoxia Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Substrate-dependent Cell Migration Signal Transduction Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Animal Organ Morphogenesis Glial Cell Proliferation Morphogenesis Of Embryonic Epithelium Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Mast Cell Chemotaxis Positive Regulation Of Lymphangiogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation Cellular Response To Leukemia Inhibitory Factor
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs
Diseases		Gastric cancer
GWAS		Blood protein levels ( 30072576) Chin dimples ( 27182965) HIV-1 viral setpoint ( 22174851) Idiopathic dilated cardiomyopathy ( 29495422) Intraocular pressure ( 29785010 31959993) Mastocytosis (KIT D816V positive) ( 33421400) Serum albumin levels ( 29403010) Serum total protein levels ( 29403010) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		3 interacting genes: FLT4 KDR SGTB
Entrez ID		7424
HPRD ID		03317
Ensembl ID		ENSG00000150630
Uniprot IDs		P49767
PDB IDs		2X1W 2X1X 4BSK 6TJT
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Activity Lymph Vessel Development Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Growth Factor Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Lung Alveolus Development Vasculature Development Positive Regulation Of Endothelial Cell Proliferation Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Protein Tyrosine Kinase Activity Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Positive Regulation Of ERK1 And ERK2 Cascade TRC Complex Positive Regulation Of Protein Phosphorylation Cellular Response To Hydrogen Sulfide Positive Regulation Of Phosphorylation Response To Hydrogen Sulfide Post-embryonic Camera-type Eye Morphogenesis Vascular Endothelial Growth Factor Binding Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Tube Morphogenesis Positive Regulation Of Phosphate Metabolic Process Angiogenesis Response To Growth Factor Positive Regulation Of Nitric Oxide Mediated Signal Transduction Sorting Endosome Endocardium Development Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Protein Phosphorylation Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Post-embryonic Eye Morphogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Modification Process Phosphorylation Regulation Of Protein Phosphorylation Vascular Wound Healing Positive Regulation Of Mitochondrial Depolarization Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Bone Development Regulation Of Phosphorylation
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