ARHGEF9 and TBC1D22B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF9	TBC1D22B
Description		Cdc42 guanine nucleotide exchange factor 9	TBC1 domain family member 22B
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GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Synapse GABA-ergic Synapse Postsynaptic Specialization	Golgi Apparatus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activator Activity Protein Binding 14-3-3 Protein Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynaptic Specialization Assembly	Regulation Of Cilium Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOQ GTPase cycle GABA receptor activation GABA receptor activation
Drugs
Diseases		Hyperekplexia Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Male-pattern baldness ( 28196072)	Acne (severe) ( 24927181) Blood glucose levels ( 31928498) Platelet count ( 27863252) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498)
Interacting Genes		12 interacting genes: BCL6 CDC42 CFTR FAM90A1 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TBC1D22B TFIP11 TSGA10IP	58 interacting genes: AP1B1 ARHGEF9 BLZF1 CALCOCO2 CARD10 CCDC57 CCDC88B CDR2 CEP63 CEP70 COG6 DAPK1 DDIT4L DEUP1 EFHC2 EXOC8 FHL3 FXR1 FXR2 GFAP GOLGA2 HMG20A HOMER3 HOOK2 HSD17B14 IKZF3 KIFC3 KRT34 KRT40 LHX8 LIMS1 LRRK2 MFHAS1 MID2 MTUS2 PICK1 PLEKHG4 PNMA5 RBM10 RBM48 REL SIAH1 SLAIN1 SORBS3 SPATA2 TACC3 TEPSIN TEX11 TP53BP2 TRIM23 TRIM27 TRIM54 TRIP6 VPS52 ZFP90 ZNF438 ZNF76 ZSCAN4
Entrez ID		23229	55633
HPRD ID		02337	15475
Ensembl ID		ENSG00000131089	ENSG00000065491
Uniprot IDs		A0A1B0GWI5 A0A5F9ZHY9 A0A5F9ZI31 B1AMR3 O43307	Q9NU19
PDB IDs		2YSQ	6D0S
Enriched GO Terms of Interacting Partners?			Cytoskeleton Identical Protein Binding Cytoplasm Protein Binding Microtubule Binding Organelle Organization Regulation Of Autophagy Trans-Golgi Network Membrane Positive Regulation Of Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Golgi Organization Microtubule-based Process Centriole Replication Cytoskeleton Organization De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Microtubule Nucleation Microtubule De Novo Centriole Assembly Centriole Assembly Microtubule Organizing Center Organization Signaling Receptor Complex Adaptor Activity Supramolecular Fiber Organization Establishment Of Protein Localization Golgi Apparatus Cytosol Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Localization Positive Regulation Of Catabolic Process Microtubule Cytoskeleton Organization Protein Transport
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