ARHGEF9 and GPHN

Number of citations of the paper that reports this interaction (PMID 10607391)
45

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		ARHGEF9	GPHN
Gene Name		Cdc42 guanine nucleotide exchange factor (GEF) 9	gephyrin
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytoskeleton Plasma Membrane Cell Junction Postsynaptic Membrane Inhibitory Synapse
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity	ATP Binding Transferase Activity Metal Ion Binding Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity
	Biological Process	Small GTPase Mediated Signal Transduction Synaptic Transmission Positive Regulation Of Rho GTPase Activity Ion Transmembrane Transport Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Transport Apoptotic Signaling Pathway	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Molybdopterin Cofactor Biosynthetic Process Small Molecule Metabolic Process Glycine Receptor Clustering
Pathways		Signaling by GPCR GABA receptor activation Signalling by NGF GABA A receptor activation Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling Ion channel transport Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS			Depression (quantitative trait) ( 23290196)
Protein-Protein Interactions		4 interactors: GPHN KHDRBS1 PLEKHA5 SMURF1	13 interactors: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MTOR PFN1 PIN1 SPATS1 TUBA4A
Entrez ID		23229	10243
HPRD ID		02337	04893
Ensembl ID		ENSG00000131089	ENSG00000171723
Uniprot IDs		B1AMR3 O43307	F5H039 F8W7D6 Q9NQX3
PDB IDs		2YSQ	1JLJ
Enriched GO Terms of Interacting Partners?		Glycine Receptor Clustering Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Positive Regulation Of RNA Export From Nucleus Establishment Of Synaptic Specificity At Neuromuscular Junction Ubiquitin-dependent SMAD Protein Catabolic Process Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Regulation Of RNA Export From Nucleus Positive Regulation Of Translational Initiation Protein Localization To Cell Surface Receptor Catabolic Process Ectoderm Development Postsynaptic Membrane Organization	Cellular Response To Stimulus Response To Stimulus Signal Transduction Apoptotic Signaling Pathway Signaling G2/M Transition Of Mitotic Cell Cycle Cell Communication Positive Regulation Of Organelle Organization Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Fatty Acid Oxidation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cytoskeleton Organization Cellular Response To Organic Substance Positive Regulation Of Intracellular Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Surface Receptor Signaling Pathway Regulation Of Rho GTPase Activity Positive Regulation Of Mitochondrion Organization Microtubule-based Process Regulation Of Stress Fiber Assembly Regulation Of Carbohydrate Utilization Synaptic Target Recognition Regulation Of Catalytic Activity Regulation Of Rho Protein Signal Transduction Exocytosis Platelet Degranulation Positive Regulation Of Translation Response To Organic Substance Transport Regulation Of Fatty Acid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Mitochondrion Organization Positive Regulation Of RNA Export From Nucleus Apoptotic Process Programmed Cell Death Regulation Of Signal Transduction Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Neural Tube Closure Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Positive Regulation Of Actin Filament Polymerization Cell Death Death
Tagcloud ?			albeit bcl2 characterizing copy cytogenetic ep300 fl gains hit hodgkin igh illustrate incompletely infrequently insufficient karyotype losses lymphoblastic lymphoma neil1 principally q21 q32 rearrangement specimen transform translocations warrant workup
Tagcloud (Difference) ?			albeit bcl2 characterizing copy cytogenetic ep300 fl gains hit hodgkin igh illustrate incompletely infrequently insufficient karyotype losses lymphoblastic lymphoma neil1 principally q21 q32 rearrangement specimen transform translocations warrant workup
Tagcloud (Intersection) ?