RCOR1 and ZMYM2

Number of citations of the paper that reports this interaction (PMID 18806873)
14

Data Source:
BioGRID (pull down)

		RCOR1	ZMYM2
Gene Name		REST corepressor 1	zinc finger, MYM-type 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcriptional Repressor Complex	Cytosol PML Body
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Transcription Regulatory Region DNA Binding	Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Blood Coagulation Viral Process Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Histone H4 Deacetylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Biological_process
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production	Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		10 interactors: CTBP1 HDAC2 HIST3H3 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 ZMYM2	20 interactors: CEBPE CREB1 FUS HNRNPA2B1 HNRNPH3 PTBP1 RCOR1 SFPQ SKIL SMAD3 SMAD4 SNIP1 SREBF2 SUMO1 SUMO2 UBE2A UBE2I UBTF ZBTB3 ZNF512B
Entrez ID		23186	7750
HPRD ID		09645	03745
Ensembl ID		ENSG00000089902	ENSG00000121741
Uniprot IDs		J3KN32 Q9UKL0	Q9UBW7
PDB IDs		2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Modification Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Nitrogen Compound Metabolic Process Histone H4 Deacetylation Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Organelle Organization Biosynthetic Process Regulation Of Hormone Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process	Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process RNA Processing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome Protein Sumoylation RNA Splicing, Via Transesterification Reactions Transcription From RNA Polymerase II Promoter RNA Splicing SMAD Protein Complex Assembly Metabolic Process MRNA Processing Regulation Of Transforming Growth Factor Beta2 Production DNA-templated Transcription, Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Epithelial Cell Differentiation MRNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Production Of MiRNAs Involved In Gene Silencing By MiRNA Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Protein Catabolic Process Lens Fiber Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Tagcloud ?		appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates gfi gfi1b h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor2 rcor3 repressing restraining sant2 sharp upsurge	advanced aggressive cassette challengeable effectively find finger formerly hairpin hcc hepatocellular immunohistochemical intensities library limitations malignancy regions relating reports responsiveness screens sequenced sorafenib stronger successful successive treat zinc
Tagcloud (Difference) ?		appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates gfi gfi1b h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor2 rcor3 repressing restraining sant2 sharp upsurge	advanced aggressive cassette challengeable effectively find finger formerly hairpin hcc hepatocellular immunohistochemical intensities library limitations malignancy regions relating reports responsiveness screens sequenced sorafenib stronger successful successive treat zinc
Tagcloud (Intersection) ?